Protein Info for CSW01_08525 in Vibrio cholerae E7946 ATCC 55056

Annotation: formate transporter FocA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 280 transmembrane" amino acids 34 to 54 (21 residues), see Phobius details amino acids 73 to 97 (25 residues), see Phobius details amino acids 110 to 134 (25 residues), see Phobius details amino acids 160 to 181 (22 residues), see Phobius details amino acids 191 to 214 (24 residues), see Phobius details amino acids 254 to 276 (23 residues), see Phobius details PF01226: Form_Nir_trans" amino acids 13 to 275 (263 residues), 262.8 bits, see alignment E=1.4e-82 TIGR04060: formate transporter FocA" amino acids 13 to 278 (266 residues), 373.3 bits, see alignment E=6e-116 TIGR00790: formate/nitrite transporter" amino acids 25 to 279 (255 residues), 267.4 bits, see alignment E=1.1e-83

Best Hits

Swiss-Prot: 54% identical to FOCA_ECO57: Probable formate transporter 1 (focA) from Escherichia coli O157:H7

KEGG orthology group: K06212, formate transporter (inferred from 100% identity to vco:VC0395_A1299)

MetaCyc: 54% identical to formate channel FocA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-1; TRANS-RXN-381

Predicted SEED Role

"Formate efflux transporter (TC 2.A.44 family)" in subsystem Fermentations: Mixed acid

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (280 amino acids)

>CSW01_08525 formate transporter FocA (Vibrio cholerae E7946 ATCC 55056)
MEHNQFDSLLPPQMAERAAITGEGKAKKAAYKSFLLAISAGIQIGIAFVFYTVVTTGAHD
MPYGVTKLLGGLAFSLGLILVVITGGELFTSSVLILVAKASGKISWKELVRNWTVVYFGN
LCGSIILVFIMLATRQFMEDGGQLGLNAMAISQHKLHHTFLQAFALGLMCNILVCLAVWM
TFSARSLTDKVMVLILPVAMFVSSGFEHCIANMFQVPMAIGIKYFAPESFWAMTGANIAQ
YADLNFVNFIVNNLIPVTLGNIVGGGVFVGMWYWLIYLKD