Protein Info for CSW01_08310 in Vibrio cholerae E7946 ATCC 55056

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1176 transmembrane" amino acids 481 to 503 (23 residues), see Phobius details PF00497: SBP_bac_3" amino acids 37 to 223 (187 residues), 48.5 bits, see alignment E=1.9e-16 amino acids 258 to 464 (207 residues), 32.5 bits, see alignment E=1.6e-11 PF00512: HisKA" amino acids 651 to 715 (65 residues), 58.9 bits, see alignment 1.1e-19 PF02518: HATPase_c" amino acids 764 to 872 (109 residues), 92.2 bits, see alignment E=7.3e-30 PF00072: Response_reg" amino acids 950 to 1063 (114 residues), 71.8 bits, see alignment E=1.3e-23 PF01627: Hpt" amino acids 1112 to 1168 (57 residues), 31.6 bits, see alignment 4e-11

Best Hits

KEGG orthology group: K07679, two-component system, NarL family, sensor histidine kinase EvgS [EC: 2.7.13.3] (inferred from 100% identity to vcj:VCD_002724)

Predicted SEED Role

"Sensory box sensor histidine kinase/response regulator VieS"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1176 amino acids)

>CSW01_08310 hypothetical protein (Vibrio cholerae E7946 ATCC 55056)
MRAADYLDPNEQAYVEQKSTVTIAVLKEIWMPYWGGTGQEPIGIEHDFASGIAKELGINI
EYKGFDTIEALLNAVSTGKADMAIGFGQTLAREGKFLFSKPLYENVRVIWLRDKAMEEKP
FASLKWVCIQGTSYCEILKDRGYPNIIMARNYSSSVEMIRQGIADATVTNYVSLNHYLSQ
KRLALGKVIFDPDLGVQTNRILINNNEPLLLSAINKVIDADKQGLTENKLNSADVYFLND
QANLNILRNENVNPVVRYTIQDDLFPMSYWDEKEKKYKGYVHDLLERISTKSILKFEFVP
AYGRDVEDMLRHGKVDLIPSFNMTYVDDRYFIHTGRYTDIQFGYIETTRPYTTPITGILD
RTGKFNAYIAVQKNLSDVKVYRSMYDLEQALEKGDITHGLLNKVLINQMLLDGHQDAFKL
SPLTEGQDLRADMTMLVRKDARGLQNMLQKVLATFSQQEIDEIKGAYDRVTVYFGYDKQK
VLIYALIILCALLSIGLILTLSLSRLRGKLRSSEQVAKLSTEQLRWLTELLDAIPSMIFI
SDAKGEVVLTNAAYRKIYHTCCEKGCVQPQPECSFLALPDQHEAEFSIIIQAPKSNCSIG
EHYFHVTRRAISHPINQRKYYLTLFNDITELKETEQALRQSNEQALQAVEARNHFLAVVS
HELRTPIAAMLGLMEILASRLKSSESQLLLTNAISSAERLKLHVNDILDFSKIEAQQLQL
DIGLYNLADELGPLLRGFEASAQLKEIEFDVIWSPNSLLLANFDALRFNQIVTNLLSNAI
KFTDQGRVVFKIDVAPEMLTIVVEDTGCGMTQTQIESLFVPFAQADSTITRRFGGTGLGM
SIVANLIELMNGKIEVKSEFEQGTQIQVNLPLVTQTCDEFRGQVVAMSYRSPYMLWAKAL
GMRVEENEEWVEQSGHNIYPDLLLNRLREVSNLTQAQTEPAHSRLLQGHVLVADDDAINR
LLIKKQLSELGLSATLVSDGLQAFEKLSQHPEQYDLLITDCHMPHLDGFALTRKVKQEIS
LFKGAVVGCTAEDSRLAAEQALQAGMDKVIYKPYTLANLRKVLSRYLTTQWVALPEQSWL
DAYQEEEREEMAMVVAESLAQDIALLNQPDCDVKALAHRIKGAAGSLQLQRLADLAKTVE
KQNDPQQLVADKQQLINAMHEVVEQAQQWLHQYQSE