Protein Info for CSW01_08200 in Vibrio cholerae E7946 ATCC 55056

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 458 transmembrane" amino acids 16 to 37 (22 residues), see Phobius details amino acids 59 to 85 (27 residues), see Phobius details amino acids 97 to 117 (21 residues), see Phobius details amino acids 137 to 158 (22 residues), see Phobius details amino acids 169 to 189 (21 residues), see Phobius details amino acids 198 to 220 (23 residues), see Phobius details amino acids 249 to 270 (22 residues), see Phobius details amino acids 290 to 308 (19 residues), see Phobius details amino acids 319 to 346 (28 residues), see Phobius details amino acids 366 to 390 (25 residues), see Phobius details amino acids 402 to 420 (19 residues), see Phobius details amino acids 426 to 443 (18 residues), see Phobius details PF01554: MatE" amino acids 25 to 185 (161 residues), 100.3 bits, see alignment E=4.9e-33 amino acids 252 to 413 (162 residues), 60.8 bits, see alignment E=6.9e-21 TIGR00797: MATE efflux family protein" amino acids 25 to 422 (398 residues), 210.8 bits, see alignment E=1.5e-66

Best Hits

KEGG orthology group: None (inferred from 100% identity to vcm:VCM66_1570)

Predicted SEED Role

"Na+ driven multidrug efflux pump"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (458 amino acids)

>CSW01_08200 MATE family efflux transporter (Vibrio cholerae E7946 ATCC 55056)
MSVVSQVLSHMRGDFFRRLIAIALPITLQNIMFSSRGLVDVLMLGQLGEAEIAAVGVAAR
ATFVTTIMLVGVTTGGALLTAQYWGAGDRKGVRESTALTWLVSNFFAFFTVLLFLFFPQQ
IMSLTTDSEQVNALGSQYLIITSFTMFAVACVSSMAVGLRAMHKPGVSTFFSGIGIVSNV
VLNWILIFGKFGFPAMGIQGAAIATVLSGAIEIACLYSYLYGKKHLMAFGWQDIKAVIDW
PKISRFLRLSLPTTFNFLIWAAGLFTYHAIMGQTGVQGLAALSVMTPVESISLSLLIGMS
TAAAVLVGNQLGAKNYEAVYYQAIGVTACSVLVGIVVAIGLYLVQIPVLGAFTALTPETR
ELSEKFMLILCLGIVLRSFPMTAIVGVLRAGGDVKFCLGQDIVAQWCIGIPLAAFAALVL
KVEPEWIYLLFLTEEVVKWFGSLHRMKSKKWMKNLIEN