Protein Info for CSW01_08180 in Vibrio cholerae E7946 ATCC 55056

Annotation: Na+/H+ antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 382 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details transmembrane" amino acids 45 to 67 (23 residues), see Phobius details amino acids 87 to 107 (21 residues), see Phobius details amino acids 115 to 136 (22 residues), see Phobius details amino acids 146 to 167 (22 residues), see Phobius details amino acids 173 to 191 (19 residues), see Phobius details amino acids 199 to 229 (31 residues), see Phobius details amino acids 249 to 269 (21 residues), see Phobius details amino acids 281 to 303 (23 residues), see Phobius details amino acids 321 to 344 (24 residues), see Phobius details amino acids 354 to 373 (20 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 7 to 373 (367 residues), 481.7 bits, see alignment E=7e-149 TIGR00773: Na+/H+ antiporter NhaA" amino acids 8 to 373 (366 residues), 629.8 bits, see alignment E=7.4e-194

Best Hits

Swiss-Prot: 100% identical to NHAA_VIBCM: Na(+)/H(+) antiporter NhaA (nhaA) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 100% identity to vcm:VCM66_1566)

MetaCyc: 62% identical to Na+:H+ antiporter NhaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-129; TRANS-RXN-292

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (382 amino acids)

>CSW01_08180 Na+/H+ antiporter NhaA (Vibrio cholerae E7946 ATCC 55056)
MSDMIRDFFKMESAGGILLVIAAAIAMVIANSAMGEGYQAFLHTYVFGMSVSHWINDGLM
AVFFLLIGLEVKRELLEGALKSRETAIFPAIAAVGGMLAPALIYVAFNFNDPAAIQGWAI
PAATDIAFALGIMALLGKRVPVSLKVFLLALAIIDDLGVVVIIALFYSSDLSTIALTIGF
IMTGVLFMLNAKHVTKLSIYLVAGLILWIAVLKSGVHATLAGVVIGFAIPLKGNKGEHSP
LKHLEHALHPYVAFAILPVFAFANAGISLQGVSLAGLTSMLPLGVALGLFLGKPLGIFSF
SWAAVKLGVAKLPEGINFKHIFAVSVLCGIGFTMSIFISSLAFGQANEAYDTYARLGILM
GSTTAALLGYSLLRLSLPLKKA