Protein Info for CSW01_07925 in Vibrio cholerae E7946 ATCC 55056
Annotation: lipid A modification system glycine--protein ligase AlmE
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to vcm:VCM66_1519)MetaCyc: 100% identical to Lipid A modification system glycine--protein ligase AlmE (Vibrio cholerae O1 biovar El Tor str. N16961)
6.2.1.-
Predicted SEED Role
"Enterobactin synthetase component F (EC 2.7.7.-)" (EC 2.7.7.-)
MetaCyc Pathways
- lipid A modification (glycine addition, Vibrio cholerae) (3/3 steps found)
KEGG Metabolic Maps
- Biosynthesis of siderophore group nonribosomal peptides
- Lipopolysaccharide biosynthesis
- Nucleotide sugars metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.7.7.-
Use Curated BLAST to search for 2.7.7.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (556 amino acids)
>CSW01_07925 lipid A modification system glycine--protein ligase AlmE (Vibrio cholerae E7946 ATCC 55056) MPYNSATDLLQREGYGVVHNQFINNMAMYCETRHSILAAIQANRHAPALWVKQKTYTYQE MTDMALSLSDYWHLQGVQRVAILSVRDLAAYSAIWASYLGGMTYIPLNARATTEQIQETL IATQCDSIMVDAQQLSRLSSLLETCIDRLHIYALPDVDVEPLRQQYPQHTFHTVQITEQD VELLVVKYHLDNEHEYAYIMQTSGSTGKPKRIAVSYSNLHCYISQIDKLFPLNAQDRVGQ YSDLTFDLSVHDIFYSLISGACLYVVPELAKLSPAEFIHHHQLTVWLSVPTVIELALQRQ TLTPHSLPSLRLSFFCGQALLHDLAEQWQQATQQPVINLYGPTECTIAVTYHRFVAHSGM ASVPIGRAFEEECLAIINEQGELMRFESAPEGYRGELLLSGKQLVKGYLNDPLNTQSAFF QHEGRLWYRSGDIVTKSNGVLIHLGRRDHQVKIAGQRVELEEIETVVRRVTQAHSVAIVP WPLSESGYASGTVAFVDTHTQWQPDLWLSQCKQQLNPTFVPKRWYAIEQLPRNANGKTDI KALQQQLASQTYETSH