Protein Info for CSW01_07850 in Vibrio cholerae E7946 ATCC 55056

Annotation: efflux RND transporter periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 377 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 35 to 367 (333 residues), 115.3 bits, see alignment E=1.4e-37 PF16576: HlyD_D23" amino acids 46 to 257 (212 residues), 59.1 bits, see alignment E=7.9e-20 PF13533: Biotin_lipoyl_2" amino acids 58 to 89 (32 residues), 30.3 bits, see alignment (E = 5.5e-11) PF13437: HlyD_3" amino acids 177 to 262 (86 residues), 39.1 bits, see alignment E=2.2e-13

Best Hits

KEGG orthology group: K02005, HlyD family secretion protein (inferred from 100% identity to vcm:VCM66_1504)

Predicted SEED Role

"Membrane-fusion protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (377 amino acids)

>CSW01_07850 efflux RND transporter periplasmic adaptor subunit (Vibrio cholerae E7946 ATCC 55056)
MAKRWTLLATLVGVGLAGGYYTLTYTPESSSPLPTLNVSRGTIEKQAVAVGQIMPSHSVA
IKSQINGIVGEIYVREGQHVEQGQPLIKVRPNPTPQALTDASTELMQSEANLESDLQRLA
NLERLVKQQIIPANYDDYVRAKADVKAKQAEVQQKRQNLELIRSGEASIGQAKLSSTLYA
PISGTILNIKVEVGEPIISTESSQAATEMIQLADMKNIVFKGSVSEHDAAQLNAGMPASI
TVAPYPEQVINGQLTKVAIQSERLNNPENKDGKSFDNGFQVEIGQLDIPENMTLRSGFSA
SAKITLQRAADVITLPERALQFEGETPMVLIADGSAQGYTAHPVKLGLSDGVQVEILEGV
AEKDSIVDNSMLGGQHE