Protein Info for CSW01_07735 in Vibrio cholerae E7946 ATCC 55056

Annotation: multidrug resistance protein NorM

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 457 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details transmembrane" amino acids 51 to 72 (22 residues), see Phobius details amino acids 92 to 114 (23 residues), see Phobius details amino acids 128 to 146 (19 residues), see Phobius details amino acids 158 to 178 (21 residues), see Phobius details amino acids 188 to 212 (25 residues), see Phobius details amino acids 239 to 263 (25 residues), see Phobius details amino acids 275 to 298 (24 residues), see Phobius details amino acids 311 to 335 (25 residues), see Phobius details amino acids 347 to 369 (23 residues), see Phobius details amino acids 386 to 407 (22 residues), see Phobius details amino acids 420 to 437 (18 residues), see Phobius details PF01554: MatE" amino acids 17 to 176 (160 residues), 133.3 bits, see alignment E=3.3e-43 amino acids 243 to 404 (162 residues), 127 bits, see alignment E=2.9e-41 TIGR00797: MATE efflux family protein" amino acids 17 to 422 (406 residues), 400.3 bits, see alignment E=4.3e-124

Best Hits

Swiss-Prot: 100% identical to NORM_VIBCH: Multidrug resistance protein NorM (norM) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 100% identity to vco:VC0395_A1146)

MetaCyc: 56% identical to multidrug efflux pump MdtK (Escherichia coli K-12 substr. MG1655)
RXN0-2561; TRANS-RXN-347; TRANS-RXN-348; TRANS-RXN-349

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (457 amino acids)

>CSW01_07735 multidrug resistance protein NorM (Vibrio cholerae E7946 ATCC 55056)
MHRYKKEASNLIKLATPVLIASVAQTGMGFVDTIMAGGVSAIDMAAVSIAASIWLPSILF
GVGLLMALVPVVAQLNGAGRQHKIPFEVHQGLILALLVSVPIIAVLFQTQFIIRFMDVEE
AMATKTVGYMHAVIFAVPAYLLFQALRSFTDGMSLTKPAMVIGFIGLLLNIPLNWIFVYG
KFGAPELGGVGCGVATAIVYWIMLLLLLFYIVTSKRLAHVKVFETFHKPQPKELIRLFRL
GFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVALNFSSLVFMFPMSIGAAVSIRVGH
KLGEQDTKGAAIAANVGLMTGLATACITALLTVLFREQIALLYTENQVVVALAMQLLLFA
AIYQCMDAVQVVAAGSLRGYKDMTAIFHRTFISYWVLGLPTGYILGMTNWLTEQPLGAKG
FWLGFIIGLSAAALMLGQRLYWLQKQSDDVQLHLAAK