Protein Info for CSW01_07660 in Vibrio cholerae E7946 ATCC 55056

Annotation: molybdenum cofactor guanylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 203 TIGR02665: molybdenum cofactor guanylyltransferase" amino acids 16 to 196 (181 residues), 238.7 bits, see alignment E=2.4e-75 PF12804: NTP_transf_3" amino acids 18 to 166 (149 residues), 140.8 bits, see alignment E=2.3e-45

Best Hits

Swiss-Prot: 100% identical to MOBA_VIBCH: Molybdenum cofactor guanylyltransferase (mobA) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03752, molybdopterin-guanine dinucleotide biosynthesis protein A (inferred from 100% identity to vco:VC0395_A1133)

MetaCyc: 43% identical to molybdenum cofactor guanylyltransferase (Escherichia coli K-12 substr. MG1655)
RXN-21601 [EC: 2.7.7.77]; 2.7.7.77 [EC: 2.7.7.77]

Predicted SEED Role

"Molybdopterin-guanine dinucleotide biosynthesis protein MobA" in subsystem Molybdenum cofactor biosynthesis

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.77

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (203 amino acids)

>CSW01_07660 molybdenum cofactor guanylyltransferase (Vibrio cholerae E7946 ATCC 55056)
MITTQTLPTLQPSDTSWVILAGGQASRMGGQDKGLIQLNGQPLVQHVIDKLAPQTPTLLI
NANRNQSQYQQFAPVISDEFPDYPGPLGGIHAGLSHAPTDWVGFVPCDSPLICDDLVARF
CQAVKPESDILVAHDGEHQQPVFTLFHKRVLPKLSAFLARGDRKIILLYDECHTSYVDFS
DAPSCFFNLNTPQELAQFGALHP