Protein Info for CSW01_07635 in Vibrio cholerae E7946 ATCC 55056

Annotation: two-component sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 677 transmembrane" amino acids 21 to 46 (26 residues), see Phobius details amino acids 315 to 338 (24 residues), see Phobius details PF17202: sCache_3_3" amino acids 201 to 314 (114 residues), 86.7 bits, see alignment E=2.6e-28 PF17201: Cache_3-Cache_2" amino acids 235 to 322 (88 residues), 50 bits, see alignment E=5.6e-17 PF00512: HisKA" amino acids 446 to 509 (64 residues), 41.1 bits, see alignment E=2.9e-14 PF02518: HATPase_c" amino acids 557 to 665 (109 residues), 84.5 bits, see alignment E=1.5e-27

Best Hits

KEGG orthology group: K02482, two-component system, NtrC family, sensor kinase [EC: 2.7.13.3] (inferred from 100% identity to vco:VC0395_A1128)

Predicted SEED Role

"Signal transduction histidine kinase"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (677 amino acids)

>CSW01_07635 two-component sensor histidine kinase (Vibrio cholerae E7946 ATCC 55056)
MKAKWAWWQKWRHRFQTTVRYRLWILTSAPIFLTLLALIAITIYWSLHYTWNSALIDVSE
RLGVAQNSVTLLQQKQANHVRAFAESYDFRKRLQEPETLSTLPRWVQNQKNRYGLDFLSF
ERVDSLEQKFRYLDLTKRESFFDVLSADELEKLDPDLAKQAQIPILNSQQIETRGLVSRT
VIPVRNDFGEIIGFLDGGLLLNNSTTLVDQIRDLIYPSHQDQLRPTGTLTLFLDDLRVST
NVPLDSNIHAGRAIGTRVSSEVFNQVLKGGQQWVNLAYVYDAWYITAYEPIRDQYHNEIG
MLYTGYLMWPFLKAYVTNILEVGIITLFLLVISGLFVYRGSRDLFRPIERIHRVVKMVQL
GKNQRIGQIGLDDKHELAQLAKQFDNMLDQLQQRNEEIVQAAHELEAKVQSRTASLQEKT
AQLEHHIALLNQTRNKLVVHEKLAALGELTAGIAHEINNPTAVILGNTELIRFELGADAS
RVEEEIDAILLQIERIRNITRSLLQYSRQGGVQDEITWQHVNPIIDESITLVKTGSKKRD
IEFVLELKAHNSVEVNRHQLLQILVNLQMNAIHAMNGKGRITIRSEDWVEEGQNRGAVIH
IEDQGCGIKPENLKRIFDPFYTTKREGTGLGLSVSQSLLSQSGGEIKVQSELGVGSTFSI
FLPSKNEAKLRETLLLQ