Protein Info for CSW01_07595 in Vibrio cholerae E7946 ATCC 55056

Annotation: formate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 951 signal peptide" amino acids 1 to 53 (53 residues), see Phobius details TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 19 to 47 (29 residues), 20.4 bits, see alignment (E = 2.5e-08) PF04879: Molybdop_Fe4S4" amino acids 62 to 112 (51 residues), 45.1 bits, see alignment 1.2e-15 PF00384: Molybdopterin" amino acids 118 to 568 (451 residues), 161.3 bits, see alignment E=5.3e-51 PF01568: Molydop_binding" amino acids 818 to 944 (127 residues), 75.4 bits, see alignment E=5.3e-25

Best Hits

KEGG orthology group: K00123, formate dehydrogenase, alpha subunit [EC: 1.2.1.2] (inferred from 86% identity to vsa:VSAL_I1453)

Predicted SEED Role

"Formate dehydrogenase-O, major subunit (EC 1.2.1.2)" in subsystem Formate hydrogenase (EC 1.2.1.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (951 amino acids)

>CSW01_07595 formate dehydrogenase (Vibrio cholerae E7946 ATCC 55056)
MRLIKRSDSVTKEQNQLGISRRAFMKNTSLAAGGAAVGASLFTPGMIRKAQASEVDRSAK
TEVKRTICSHCSVGCGIYAEVQNGVWTGQEPAFDHPFNAGGHCAKGAALREHGHGERRLK
YPMKLEGGKWKKISWEQAINEIGDKALKIREESGPDSVYFLGSAKHSNEQAYLFRKMASL
WGTNNVDHQARICHSTTVAGVANTWGYGAMTNSFNDMHNCKSMLFIGSNPAEAHPVAMQH
ILIAKEKNSCKIVVADPRRTRTAAKADYFVSLRPGSDVAFIWGVLWHVFKNNWEDKEYIR
QRVFGMDEIRAEVAKWTPAEVERVTGVSEEEVYNTAKTLAENRPGCVVWCMGGTQHTTGN
NNTRAYCILELALGNIGKSGGGANIFRGHDNVQGATDLGVLSDTLPGYYGLTEGSWKHWA
SVWGVDFEWIKNRFDQGTYNGALPMETPGIPVSRWIDGVLENKDNLQQRENIRAMFYWGH
AVNSQTRGVEMKKAMQKLDMMVIVDPYPTVAAVMNDRTDGVYLLPATTQFETYGSVTASN
RSIQWRDQVIEPLFESKPDHEIMYLLSQKLGIADQLCKHIRVENNQPLIEDITREFNRGM
WTIGYTGQSPERLKTHQQNWHTFHKTTLAAEGGPAHGDTYGMPWPCWGTPEMKHPGTHIL
YDTSKTVAEGGGNFRTRFGVEFEGKSLLAEDSYSKGCELQDGYPEFSDKLLKQLGWWDDL
TAEEKAAAEGKNWKTDLSGGIQRVAIKHGCIPFGNAKARAIVWTFPDRVPLHREPLYTPR
RDLLADYPTWDDQAFIFRVPTLYKSIQAQDKSVEYPIILTSGRLVEYEGGGEETRSNPWL
AELQQEMFVEVNPKDANDLGFMDGDMVWVEGAEKGRIKVKAMVTRRVKPGMAFLPFHFGG
KFQGEDLRPKYPEGTQPYVVGEAANTATTYGYDPVTLMQETKVTLCNIRKA