Protein Info for CSW01_07585 in Vibrio cholerae E7946 ATCC 55056

Annotation: formate dehydrogenase subunit gamma

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 357 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details transmembrane" amino acids 93 to 117 (25 residues), see Phobius details amino acids 137 to 157 (21 residues), see Phobius details amino acids 180 to 199 (20 residues), see Phobius details amino acids 240 to 263 (24 residues), see Phobius details amino acids 275 to 296 (22 residues), see Phobius details TIGR01583: formate dehydrogenase, gamma subunit" amino acids 125 to 330 (206 residues), 296.6 bits, see alignment E=5.6e-93 PF01292: Ni_hydr_CYTB" amino acids 128 to 309 (182 residues), 106.2 bits, see alignment E=1.8e-34

Best Hits

KEGG orthology group: K00127, formate dehydrogenase, gamma subunit [EC: 1.2.1.2] (inferred from 100% identity to vcj:VCD_002864)

Predicted SEED Role

"Formate dehydrogenase -O, gamma subunit (EC 1.2.1.2)" in subsystem Anaerobic respiratory reductases or Formate hydrogenase (EC 1.2.1.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (357 amino acids)

>CSW01_07585 formate dehydrogenase subunit gamma (Vibrio cholerae E7946 ATCC 55056)
MAMRQQLSRATRFVLPLLAALLCWLAQPVMAEENAKPDVVQKEMTQLAGADFWRQVRQGE
AGYTTSQSPEHGVLISKPGETWFILKEKWMSPAGAVAIFGSIAMVVLAYIAVGPLMLSKP
RTGRKLNRWSRSDRALHWSMAFTFLTLAFSGLMLVYGKHFLKPYIPSELWGWIIYAAKQY
HNYMGPLFFILLMFVLLKWWRKSIFNKVDVQWFMKLGGMVGKYKGTHPSAGFSNAGEKAI
YWLLIVFGTFAAISGLVLDFPIFGQTRRDMELSNLIHMLSALILICGFIFHIYIGLFGME
GALEGMVTGKVDETWAKEHHDLWYEEVKRRGEIEEASTESQPASFNQTKGEVSHESR