Protein Info for CSW01_07495 in Vibrio cholerae E7946 ATCC 55056

Annotation: NAD-glutamate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1613 PF21075: GDH_ACT1" amino acids 36 to 172 (137 residues), 157 bits, see alignment E=1.2e-49 PF21073: GDH_HM1" amino acids 340 to 399 (60 residues), 85.4 bits, see alignment (E = 7.7e-28) PF21076: GDH_ACT2" amino acids 403 to 492 (90 residues), 117 bits, see alignment 1.8e-37 PF21079: GDH_HM2" amino acids 498 to 542 (45 residues), 62.8 bits, see alignment (E = 9.5e-21) PF21077: GDH_ACT3" amino acids 548 to 627 (80 residues), 97.4 bits, see alignment 1.3e-31 PF21078: GDH_HM3" amino acids 644 to 709 (66 residues), 105.2 bits, see alignment (E = 6.2e-34) PF05088: Bac_GDH_CD" amino acids 725 to 1219 (495 residues), 896.4 bits, see alignment E=1.8e-273 PF21074: GDH_C" amino acids 1264 to 1603 (340 residues), 409.8 bits, see alignment E=3.8e-126

Best Hits

KEGG orthology group: K00260, glutamate dehydrogenase [EC: 1.4.1.2] (inferred from 58% identity to avr:B565_1958)

Predicted SEED Role

"NAD-specific glutamate dehydrogenase (EC 1.4.1.2), large form" in subsystem Glutamate dehydrogenases or Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis (EC 1.4.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1613 amino acids)

>CSW01_07495 NAD-glutamate dehydrogenase (Vibrio cholerae E7946 ATCC 55056)
MTARETLMPVLLEKVYQLIQDKLELAQQPLVTQLGQHLFSNISQDDLVERNESDLYGAVL
SLWHHINEKKADERSVRVFNPTVSRQGWQSTHTIVEIVLPDSPFLVDSIKMALSRLGLAS
HLMLNGPAHIARHDDGSIKSINQGEGQLTSMFHIEVDRLSSKEEMTELKNELLDILHDTA
LVVKDWKPMATKLEQVINQLEADKKQIPVEAERLQETIQFLRWLGNHNFTFMGYKEFDLV
EKNGDTELTPTKDTGLGLFSDNERVRSVKLSQFPDSARLEAKKPFLLILTKGNKQSRIHR
PAYTDYIGIKKFDAKGKVIGEHRFTGLYTSAVYNQSVEGIPLIREKVGRILAASGYRQGS
YAYKALHNILENYPRDELLQAREEELLEVGMGVVQMQDRDLLRLFVRKDPFGRFFSCMVY
VTKERYNTELRRKTQQVFKQYFGCEQDVEFTTYFSESPLARTHYIVRVDNNNINVDVKKI
EQNLMEASTSWDDRLAEAIVANFGESRGLPLSKEYQRAFPRSYKEDVMPGSALADIEHLE
ALDEHNKLGMLFYRLQETAKDSKAVRLKLYHKDEPIHLSDVMPMLENLGLRVIGESPYEV
VKANGQVYWILDFSMLHKSDKQVDLREARDRFQQAFAAIWAGELESDGFNRLILGASLSG
REVSILRAYARYMRQVGFPFSQHYIEDTLSHHPDLAQGLVDLFVRRFDPKYKGGEKGQAE
IIKSLTEQLDQVQSLDDDRIIRRYMEMINATLRTNYYQLDEHKQNKPWLSLKMKPSEIPE
IPAPVPAFEIFVYAPDIEGVHLRGGKVARGGLRWSDRQEDFRTEILGLVKAQQVKNTVIV
PVGAKGGFVCKKQYLYTTRDEIFAEGQRCYKRFIRALLDVTDNIIEGQVVPPKNVVRHDE
DDPYLVVAADKGTATFSDLANSVSAEYQFWLGDAFASGGSNGYDHKAMGITAKGGWESVK
RHFREMGIDCQTTDFTAIGIGDMAGDVFGNGMLLSKHIRLLAAFNHIHIFIDPTPDSASS
WEERNRLFNLPRSSWEDYNPKLISKGGGVFSRKAKAITLTPEMQKMLNTKKTTLAPNELI
KMILKMEVDLLWNGGIGTYVKSSIETHTDVGDRANDGLRVDGREVNAKIIGEGGNLGMTQ
RGRIEFALKGGRVNTDFVDNVGGVDCSDNEVNIKIFLNGLVANGDLTLKQRNQILESMKD
EVGSIVIEDAYGQSESISVTEAQGVSLMKEQIRFIHHMEKAGYLDRALEHIPDDETLLER
ERQGMGLTRPELSVLMAYGKMALKEELASEEIAQDEFHAKQLVNYFPTELRGHYAQQMVN
HPLRVEIIATALANQMVNEMGCNFVTRLQEETGSSVVDIANAYAAAREIYGLGIVLEKVR
KLDNIAQSSAQYDVMFLVRRTLRRLTRWLLRNRTGKPSVIAMVERYQEDVKAITEQLDKV
LVKEEIVEHNSMAENWIEKGIEKELAHYVARLSSLYSVLDISAVAKEKGIAVTQTAKLYF
HLGDRLSLHWFLKQINHQAVDNHWQALARASFREDLDWQQRQLTAQVLSSNLSDAQQEIE
LALDKWLERNQVSISRWENILSEFKVGTVHEFAKFSVALRELTLLNLNCLTVE