Protein Info for CSW01_07275 in Vibrio cholerae E7946 ATCC 55056

Annotation: multifunctional autoprocessing toxin RtxA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 500 1000 1500 2000 2500 3000 3500 4000 4558 PF07634: RtxA" amino acids 114 to 131 (18 residues), 10.3 bits, see alignment (E = 0.00039) amino acids 134 to 151 (18 residues), 15 bits, see alignment (E = 1.2e-05) amino acids 154 to 171 (18 residues), 14.9 bits, see alignment (E = 1.4e-05) amino acids 174 to 197 (24 residues), 7.3 bits, see alignment (E = 0.0038) amino acids 200 to 217 (18 residues), 10.2 bits, see alignment (E = 0.00043) amino acids 220 to 237 (18 residues), 7.6 bits, see alignment (E = 0.0031) amino acids 268 to 285 (18 residues), 8.7 bits, see alignment (E = 0.0013) amino acids 288 to 305 (18 residues), 10.8 bits, see alignment (E = 0.00028) amino acids 594 to 611 (18 residues), 7.9 bits, see alignment (E = 0.0023) amino acids 614 to 630 (17 residues), 10.4 bits, see alignment (E = 0.00038) amino acids 634 to 651 (18 residues), 15 bits, see alignment (E = 1.2e-05) amino acids 654 to 668 (15 residues), 7.1 bits, see alignment (E = 0.0042) amino acids 751 to 763 (13 residues), 6.7 bits, see alignment (E = 0.0056) amino acids 769 to 781 (13 residues), 10.9 bits, see alignment (E = 0.00027) amino acids 792 to 809 (18 residues), 15.6 bits, see alignment (E = 8.1e-06) amino acids 811 to 827 (17 residues), 16 bits, see alignment (E = 6.1e-06) amino acids 830 to 846 (17 residues), 15.5 bits, see alignment (E = 8.7e-06) amino acids 851 to 865 (15 residues), 11.7 bits, see alignment (E = 0.00014) amino acids 868 to 885 (18 residues), 13.8 bits, see alignment (E = 2.9e-05) amino acids 887 to 901 (15 residues), 13.4 bits, see alignment (E = 4e-05) amino acids 906 to 922 (17 residues), 10.9 bits, see alignment (E = 0.00026) amino acids 925 to 942 (18 residues), 13.5 bits, see alignment (E = 3.8e-05) amino acids 944 to 961 (18 residues), 11.1 bits, see alignment (E = 0.00022) amino acids 982 to 995 (14 residues), 8.2 bits, see alignment (E = 0.0019) amino acids 1001 to 1017 (17 residues), 17.2 bits, see alignment (E = 2.4e-06) amino acids 1025 to 1037 (13 residues), 8 bits, see alignment (E = 0.0022) amino acids 1041 to 1053 (13 residues), 13.9 bits, see alignment (E = 2.9e-05) amino acids 1077 to 1091 (15 residues), 10 bits, see alignment (E = 0.00052) amino acids 1097 to 1112 (16 residues), 13.4 bits, see alignment (E = 3.9e-05) amino acids 1120 to 1132 (13 residues), 9.7 bits, see alignment (E = 0.00062) amino acids 1135 to 1149 (15 residues), 9.8 bits, see alignment (E = 0.00056) amino acids 1155 to 1169 (15 residues), 7.8 bits, see alignment (E = 0.0027) amino acids 1173 to 1190 (18 residues), 12.3 bits, see alignment (E = 9.1e-05) amino acids 1194 to 1209 (16 residues), 16.7 bits, see alignment (E = 3.5e-06) amino acids 1211 to 1227 (17 residues), 17.3 bits, see alignment (E = 2.3e-06) amino acids 1230 to 1247 (18 residues), 11.3 bits, see alignment (E = 0.00019) amino acids 1268 to 1285 (18 residues), 8.1 bits, see alignment (E = 0.0021) amino acids 1306 to 1323 (18 residues), 18.4 bits, see alignment (E = 1e-06) amino acids 1325 to 1342 (18 residues), 12.1 bits, see alignment (E = 0.0001) PF16671: ACD" amino acids 1986 to 2371 (386 residues), 795.7 bits, see alignment E=2.2e-243 PF11647: MLD" amino acids 2574 to 2659 (86 residues), 110.8 bits, see alignment (E = 1.3e-35) PF12146: Hydrolase_4" amino acids 3194 to 3308 (115 residues), 38.8 bits, see alignment (E = 3e-13) PF00561: Abhydrolase_1" amino acids 3195 to 3303 (109 residues), 43 bits, see alignment (E = 2e-14) PF11713: Peptidase_C80" amino acids 3469 to 3626 (158 residues), 185.8 bits, see alignment (E = 2.8e-58) PF21735: RtxA_C" amino acids 3936 to 3953 (18 residues), 19.8 bits, see alignment (E = 2.7e-07) amino acids 4243 to 4260 (18 residues), 23.1 bits, see alignment (E = 2.4e-08) amino acids 4261 to 4278 (18 residues), 19.2 bits, see alignment (E = 4.3e-07) amino acids 4315 to 4331 (17 residues), 18 bits, see alignment (E = 9.7e-07) amino acids 4334 to 4349 (16 residues), 9 bits, see alignment (E = 0.00073) amino acids 4389 to 4405 (17 residues), 12.6 bits, see alignment (E = 5.3e-05)

Best Hits

Predicted SEED Role

"RTX toxins determinant A and related Ca2+-binding proteins"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (4558 amino acids)

>CSW01_07275 multifunctional autoprocessing toxin RtxA (Vibrio cholerae E7946 ATCC 55056)
MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVG
SIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVS
IDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNK
LDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQG
AGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGS
GNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKIN
KVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQ
QSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQ
PNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNP
MGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNV
IKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANV
LVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHT
QIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHIS
NDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKV
GNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEG
NAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTL
AAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAALMVGKANIMTHVGDGTSLGLF
AGEVNVMTKVGNGTTLAAMFGKANIMTHVGDGLTGVLALGEANIVTKLGDDFMGVVAAAK
ANVVTHVGDATTAAVLAGKGNILTKVGEGTTVGLLISDVGNVMTHVGDGTTIGIAKGKAN
LITKVGDGLGVNVTWGQANVFTQVGDGDRYNFAKGEANLITKVGDGQEVSVVQGEANIIT
HVGNGDDYTGAWGKANVITKVGHGQNVVLAKGEANIVTQVGDGDSFNALWSKGNIVTKVG
DGMQVTAAKGQANITTTVGNGLNVTAAYGDANINTKVGDGVSVNVAWGKYNINTKVGDGL
NVAVMKGKANANIHVGDGLNINASYAQNNVAIKVGNGDFYSLAVASSNTSSNKLSALFDN
IKQTVLGVGGSQAINYLVQGDEASSSGTHKGRGAIATPEITKLDGFQMDAIKEVSSDLGD
SLTGSVTKVDTPDLNKMQHALNVDDSSVQAPNLIVNGDFELGEHGWQSTHGVEASYAGSV
YGVEGEGHGARVTELDTYTNTSLYQDLANLAQGEVIAVSFDFAKRAGLSNNEGIEVLWNG
EVVFSSSGDESAWQQKNLKLTAQAGSNRIEFKGTGHNDGLGYILDNVVATSESSQQANAI
REHATQNPAAQNALSDKERAEADRQRLEQEKQKQLDAVAGSQSQLESTDQQALENNGQAQ
RDAVKEESEAVTAELAKLAQGLDVLDGQATHTGESGDQWRNDFAGGLLDGVQSQLDDAKQ
LANDKIAAAKQTLSDNNSKVKESVAKSEAGVAQGEQNRAGVEQDIADAQADAEKRKADAL
AKGKDAQQAESDAHHAVNNAQSRGDRDVQLAENKANQAQADAQGAKQNEGDRPDRQGVTG
SGLSGNAHSVEGAGETDSHVNTDSQTNADGRFSEGLTEQEQEALEGATNAVNRLQINAGI
RAKNSVSSMTSMFSETNSKSIVVPTKVSPEPERQEVTRRDVRISGVNLESLSAVQGSQPT
GQLASKSVPGFKSHFASTSIGIENELSGLVVVLPKNSAQTFGYVHDSQGNPLFMLTKDMN
QGGYSNPVGINDIQGVNNWQTHTIELVTYPSEISDTAAVESRKEAMLWLAKEFTDHINQS
NHQSLPHLVSDDGRFTLVISNSKHLIAAGNGTSIDAQGKTIGMTPSGQQATMAISAKEFG
TSSSPEVRLLESAPWYQAGLRDEFLANAKNTTLDDPATAQNVYAYLTSVYSKTADLAKEY
GIYINDWDPASEGFSPNAQGLTDPKVKNAWSILPRTKPVRMLELLSAEDSRYVRQQIAEK
LKGTYSESLAKNVFEYFQYGGEVAGHGINNATTGSVQQPEPAILFEFRSVPSALSDFVPK
TASTVKVDVKALDHFDSASRKAIITEVNALVSGSEDFDAWYQEYRASKGQPPVKNPKSSA
SANHKAEWLMTQHAEQWAKITAPYTDNHETLTSTKLASNDKEELHALGETSNLENNKQQE
NVASIINTMLNDMLPFYALRTERNLLVQEGDEGFEVRAWPGTEDKSKTIILEDPEDAAQH
KAIERFILANFDNFEQMPDELFLVDNKVISHHEGRTHVLAQKVDGAWQYNATVELMSVTE
LLDAANVTGKIRGESYQQVIDALTDYHASITEHADYEPESVEKLLNLRKKIEGYVLGHPD
SGRVEAMNSLLNQVNTRLDEVSLLSVAEQTIQAQNSFSRLYDQLEAANLKESKHLYLDQN
GDFVTKGKGNLANIDLLGSREAVLEKVKLTVSNEYGQTVADTIFAGLSAKDLAKDGKGVD
IAGLNKVHQAIEQHLSPVSATLYIWKPSDHSALGHAALQIGQGRTQLEGQAAADFNQQNY
VSWWPLGSKSSNISNILNVATKDQPDLKLRWSDFSQPAHQNDTLEHDVASEENDGFGLHD
GDIKLKRFIEKLNAAKGIDASFKEASEGYASVLLGNPDMLETTSIPAHVFQPFVEQWNDT
SYDMMDVAHRFAQELRLQAQRSDDPELLEKRIGNVIRQFAERALEEIETFKASQADQGRV
FRINLEGLDVAAMQAEWHRLSNDPDARYQLLTKNCSSTVAKVLKAGGADKLIGHTWLPKF
GVWTPTELFNFGQALQEAQLEIAAKKQSHQVTDVLDALSGNEKPKENVAIENDGTPPRDK
ESLSPLTRFLNNELYGDKEARRKIGEITQTLLDHAVEKGESQKITLQGEAGRLTGYYHQG
TAPSEGETSSPSGKVVLFLHGSGSSAEEQASAIRNHYQKQGIDMLAVNLRGYGESDGGPS
EKGLYQDARTMFNYLVNDKGIDPSNIIIHGYSMGGPIAADLARYAAQNGQAVSGLLLDRP
MPSMTKAITAHEVANPAGIVGAIAKAVNGQFSVEKNLEGLPKETSILLLTDNEGLGNEGE
KLRTKLTASGYNVTGEQTFYGHEASNRLMSQYADQIVSGLSSSASVDEDLDQQGLDTTST
KDQGISNKNDHLQVVDSKEALADGKILHNQNVNSWGPITVTPTTDGGETRFDGQIIVQME
NDPVVAKAAANLAGKHAESSVVVQLDSDGNYRVVYGDPSKLDGKLRWQLVGHGRDHSETN
NTRLSGYSADELAVKLAKFQQSFNQAENINNKPDHISIVGCSLVSDDKQKGFGHQFINAM
DANGLRVDVSVRSSELAVDEAGRKHTKDANGDWVQKAENNKVSLSWDAQGEVVAKDERIR
NGIAEGDIDLSRIGVNNVDEPARGAIGDNNDVFDAPEKRKPETEVIANSSSSNQFSYSGN
IQVNVGEGEFTAVNWGTSNVGIKVGTGGFKSLAFGDNNVMVHIGDGESKHSVDIGGYQAL
EGAQMFLGNRNVSFNFGHSNDLILMMDKSIPTPPLVNPFDGAARISGVLQGIATSGEGED
WLAAQEQQWTLSGAKKFVKDMSGLDQSSSVDYTTLVELDSQNERDSRGLKHDAEATLNKQ
YNQWLSGNGNSGTSQLSRADKLRQANEKLAFNFAVGGQGADIQVTTGNWNFMFGDNIQSI
LDTNLGSLFGLMTQQFTATGQAKTTFTYTPQDLPRQLKNKLLGQLAGVGAETTLADIFGV
DYTASGQIVSRNGQAVDGVAILKEMLEVIGEFSGDQLQAFVDPAKLLDSLKAGIDMGADG
IKSFAETHGLKEKAPEEEKDNSSVSVNGANVNSAQGATVADGNTETAETQDRAFGFNSLN
LPNLFATIFSQDKQKEMKSLVENLKQNLTADLLNMKEKTFDFLRNSGHLQGDGDINISLG
NYNFNWGGDGKDLGAYLGDNNNFWGGRGDDVFYATGKSNIFTGGEGNDMGVLMGRENMMF
GGDGNDTAVVAGRINHVFLGAGDDQSFVFGEGGEIDTGSGRDYVVTSGNFNRVDTGDDQD
YSVTIGNNNQVELGAGNDFANIFGNYNRINAGAGNDVVKLMGYHAVLNGGDGDDHLIATA
ISKFSQFNGGEGRDLMVLGGYQNTFKGGTDVDSFVVSGDVIDNLVEDIRSEDNIVFNGID
WQKLWFERSGYDLKLSILRDPSNDSDQSKFEHIGSVTFSDYFNGNRAQVVIGMSEKDLSG
EREYTMLSDSAIDALVQAMSGFEPQAGDNGFIDSLESKSQAAISMAWSDVVHKKGLMV