Protein Info for CSW01_07225 in Vibrio cholerae E7946 ATCC 55056

Annotation: cytochrome-c oxidase, cbb3-type subunit II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00781: cytochrome c oxidase, cbb3-type, subunit II
  • amino acids 9 to 188 (180 residues), 274.2 bits, E=5e-86
• PF02433: FixO
  • amino acids 9 to 186 (178 residues), 272.2 bits, E=1.5e-85

Best Hits

KEGG orthology group: K00405, cb-type cytochrome c oxidase subunit II [EC: 1.9.3.1] (inferred from 100% identity to vco:VC0395_A1052)

MetaCyc: 67% identical to cbb3-1 cytochrome c oxidase subunit O (Pseudomonas putida KT2440)
CYTOCHROME-C-OXIDASE-RXN [EC: 7.1.1.9]

Predicted SEED Role

"Cytochrome c oxidase subunit CcoO (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

• aerobic respiration I (cytochrome c) (3/4 steps found)
• aerobic respiration II (cytochrome c) (yeast) (3/4 steps found)
• arsenite to oxygen electron transfer (1/2 steps found)
• arsenite to oxygen electron transfer (via azurin) (1/3 steps found)
• Fe(II) oxidation (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1 or 7.1.1.9

Protein Sequence (206 amino acids)

>CSW01_07225 cytochrome-c oxidase, cbb3-type subunit II (Vibrio cholerae E7946 ATCC 55056)
MSSNSNNRHELLERNVGLLAIFIVFAISWGALVEITPLIFQKQTTEEVQNLKPYTALQLE
GRDIYIREGCNVCHSQMVRPFRSETERYGHYSVAGESVWEHPFLWGSKRTGPDLARVGGR
YSDEWHRVHLLNPRELVPESNMPAFPWLAKNTLDGKYTQQKMTLFRDKFGVPYTDEQIAN
ATKDVEGKTEMDAIIAYLQSLGHAMK