Protein Info for CSW01_07205 in Vibrio cholerae E7946 ATCC 55056

Annotation: copper-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 790 transmembrane" amino acids 175 to 197 (23 residues), see Phobius details amino acids 211 to 232 (22 residues), see Phobius details amino acids 244 to 265 (22 residues), see Phobius details amino acids 271 to 289 (19 residues), see Phobius details amino acids 420 to 441 (22 residues), see Phobius details amino acids 448 to 471 (24 residues), see Phobius details amino acids 742 to 759 (18 residues), see Phobius details amino acids 764 to 785 (22 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 4 to 86 (83 residues), 99.9 bits, see alignment E=2.7e-32 PF00403: HMA" amino acids 93 to 154 (62 residues), 42.8 bits, see alignment 1.4e-14 TIGR01511: copper-translocating P-type ATPase" amino acids 228 to 784 (557 residues), 513.6 bits, see alignment E=1.6e-157 TIGR01525: heavy metal translocating P-type ATPase" amino acids 245 to 784 (540 residues), 547.6 bits, see alignment E=8.2e-168 TIGR01512: cadmium-translocating P-type ATPase" amino acids 272 to 786 (515 residues), 420.3 bits, see alignment E=2.2e-129 TIGR01494: HAD ATPase, P-type, family IC" amino acids 279 to 762 (484 residues), 256.3 bits, see alignment E=8.8e-80 PF00122: E1-E2_ATPase" amino acids 318 to 478 (161 residues), 163.7 bits, see alignment E=8.5e-52 PF00702: Hydrolase" amino acids 499 to 695 (197 residues), 89.8 bits, see alignment E=7.8e-29 PF08282: Hydrolase_3" amino acids 676 to 715 (40 residues), 22.1 bits, see alignment 2.9e-08

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to vcj:VCD_002909)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (790 amino acids)

>CSW01_07205 copper-translocating P-type ATPase (Vibrio cholerae E7946 ATCC 55056)
MDKTCYHCGEDVPAGTNFHVDILGEQRDMCCPGCQTVAQTIVDSGLVSYYQFRTAPAEKV
ELVPEQLKALIHYDNSDVQAEFVRSKDDHSEVTLSLDGVSCAACAWLIEKQLHTEPGVVS
IRVNTTTNRALLSWDRTKTQLSHVLAQIHKLGYKAAPFEADKHEAQYHDAMKTYLYRLGI
AGLASMQVMMLAVALYLEAFGDLDAEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIRG
RTLGMDVPVSLALIFAYIASLVATITEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAA
SGNLLKLIPAIATTLDGQQVPVKTLKPGDCVRVLPGEHIPADGEIINNRVHIDESMLTGE
SLPVVKATGDHVFAGTLNGDESFDLRVTASKADSVISNIVRLQDDAQSSKPKIAEIADIV
ARYFVAIILVIAAGTWFFWHQVRPEDAFWIMLSVLVATCPCALSLATPTALTCATSSMGS
VGVMLRKNHVFETLCKVNHLVIDKTGTLTHGNIEISTVETLDSLTKESCLAIAAELESHA
NHPIAKAFRPYKAENVTVSEVRNIIGSGMEGVFAGQKVKIGSAEFVLGNPLDSAHNCVFL
SLDGRHVATFHYRDPIRKEAKAFIEKFHAAGIKITLLTGDSQTNAQSVANEMQIDKVVAQ
AKPEDKLTYLRELNKTDVTMMVGDGINDAPTLAGAHISVAMGGGTDVAKASADMVLIGDR
LDKLLEARELALKTRKIIRENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVTN
SLRLLKKQGR