Protein Info for CSW01_07160 in Vibrio cholerae E7946 ATCC 55056

Annotation: spermidine/putrescine ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 377 PF00005: ABC_tran" amino acids 35 to 174 (140 residues), 134.3 bits, see alignment E=4.6e-43 TIGR01187: polyamine ABC transporter, ATP-binding protein" amino acids 48 to 371 (324 residues), 522.5 bits, see alignment E=1.9e-161 PF08402: TOBE_2" amino acids 292 to 371 (80 residues), 45.2 bits, see alignment E=8.5e-16

Best Hits

Swiss-Prot: 100% identical to POTA_VIBCH: Spermidine/putrescine import ATP-binding protein PotA (potA) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K11072, spermidine/putrescine transport system ATP-binding protein [EC: 3.6.3.31] (inferred from 100% identity to vco:VC0395_A1039)

MetaCyc: 72% identical to spermidine preferential ABC transporter ATP binding subunit (Escherichia coli K-12 substr. MG1655)
ABC-25-RXN [EC: 7.6.2.11, 7.6.2.16]; 7.6.2.11 [EC: 7.6.2.11, 7.6.2.16]

Predicted SEED Role

"Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1)" in subsystem Polyamine Metabolism (TC 3.A.1.11.1)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.3.31 or 7.6.2.11 or 7.6.2.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (377 amino acids)

>CSW01_07160 spermidine/putrescine ABC transporter ATP-binding protein (Vibrio cholerae E7946 ATCC 55056)
MGEIQTLNEQHSVGKPVIRLSGISKSFDGKEIIGNLNLDVNHGEFLTILGPSGCGKTTVL
RMIAGFETADQGQILLDDQDVTQVPAEQRHVNTVFQSYALFPHMTVFENVAFGLRMQKVP
QSEIEPRVMEALRMVRLAEMAQRKPHQLSGGQQQRIAIARAVVNKPKVLLLDESLSALDY
KLRKQMQSELKQLQRQLGITFIFVTHDQEEALSMSDRIIVMRSGKIEQDGSPREIYEDPK
NLFVARFIGEINVFQATTIDRIDEKRIRVDIEGIESIVYYEDEVKAGDKLQVLLRPEDLR
IEEIKESEEKGIVGHVTDRTYKGMTLESVVELESGMCVMVSEFFNEDDPDVDHSIGQKVA
VTWVESWEVVLNDEQKA