Protein Info for CSW01_07075 in Vibrio cholerae E7946 ATCC 55056

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 511 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details amino acids 86 to 105 (20 residues), see Phobius details amino acids 111 to 133 (23 residues), see Phobius details amino acids 144 to 166 (23 residues), see Phobius details amino acids 172 to 194 (23 residues), see Phobius details amino acids 206 to 225 (20 residues), see Phobius details amino acids 237 to 256 (20 residues), see Phobius details amino acids 277 to 300 (24 residues), see Phobius details amino acids 309 to 329 (21 residues), see Phobius details amino acids 341 to 358 (18 residues), see Phobius details amino acids 370 to 392 (23 residues), see Phobius details amino acids 405 to 421 (17 residues), see Phobius details amino acids 477 to 498 (22 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 22 to 498 (477 residues), 433.2 bits, see alignment E=6.4e-134 PF07690: MFS_1" amino acids 24 to 417 (394 residues), 175.3 bits, see alignment E=2.6e-55 PF00083: Sugar_tr" amino acids 26 to 192 (167 residues), 23.7 bits, see alignment E=3.3e-09 PF06609: TRI12" amino acids 38 to 322 (285 residues), 33.1 bits, see alignment E=3.4e-12

Best Hits

Swiss-Prot: 43% identical to FARB_NEIGO: Fatty acid resistance protein FarB (farB) from Neisseria gonorrhoeae

KEGG orthology group: K03446, MFS transporter, DHA2 family, multidrug resistance protein B (inferred from 100% identity to vcm:VCM66_1366)

Predicted SEED Role

"Inner membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (511 amino acids)

>CSW01_07075 MFS transporter (Vibrio cholerae E7946 ATCC 55056)
MSHNADNEMQPLSGWALFFGALCLAMANFLAILDTTIANVSVSNIAGSLGTSTSQGTYVI
TSYAVAEAISVPLTGWLASRFGSIRVFVTCFLLFGVFSLLCGLANSMSTLVMFRVLLGFV
GGPLMPLSQTLMIRIFPKNKSHAAIGIWSMTTLVAPIMGPILGGVLCDQLSWPYIFFIKM
PFAIAAALLCWKLLKKFETKTTHSKIDKVGLALLVVWVAALQLMLDEGKDHDWFESSRIV
FLAVIAVIGFIAFLIWELTERNPVVDLKVFRHRGYSISMVTLSLAFGAFFSISVVTPLWL
QIYMGYTATISGHATASMGILAVFLAPIVANLSSKFDPRPFVFAGVMWLGLWTFMRGFNT
VDMTFSQISWPLFFQGIGMPLFFVPLTAIALGSVKPHEMESAAGLMNFIRTLSGAFATSM
INTSWEHETRYVHAELAGLTDKAGVATQAMQNSGMSAEQTRSAMDWILQNQSVMVATNQL
FIVIALIFVFAACMIWFAPKPKQAVDTSAVH