Protein Info for CSW01_06880 in Vibrio cholerae E7946 ATCC 55056

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 667 signal peptide" amino acids 1 to 46 (46 residues), see Phobius details transmembrane" amino acids 467 to 486 (20 residues), see Phobius details PF13424: TPR_12" amino acids 194 to 258 (65 residues), 32.2 bits, see alignment E=5.1e-11 PF13181: TPR_8" amino acids 230 to 258 (29 residues), 13.4 bits, see alignment (E = 3.6e-05) amino acids 273 to 294 (22 residues), 18.2 bits, see alignment (E = 1.1e-06) amino acids 350 to 379 (30 residues), 13.4 bits, see alignment (E = 3.7e-05) amino acids 387 to 413 (27 residues), 12.5 bits, see alignment (E = 7.5e-05) PF13176: TPR_7" amino acids 272 to 294 (23 residues), 14 bits, see alignment (E = 2.2e-05) TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 494 to 651 (158 residues), 64.5 bits, see alignment E=4.9e-22 PF00990: GGDEF" amino acids 497 to 649 (153 residues), 60.2 bits, see alignment E=1.1e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A0979)

Predicted SEED Role

"GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (667 amino acids)

>CSW01_06880 GGDEF domain-containing protein (Vibrio cholerae E7946 ATCC 55056)
MFIKLMRNIFSELTSHIQNMKLYFKRSLLVFSLMSSFCVASERSAWEEVYAKSQHKQTET
ALKLLQDRYHSLPEGAEKLYLTSKLHGYFVLKGQPYYGELVNSHDTYALTEQRFLDALNH
EESLDYHSAEETYLTFYAEMKQKNDQDGMVLFEYHLCRLFQRHGRPYQARFYCSQMDQRL
LNAEDPLFPRYRGLHLVANNLEFLGEYEEALQTYDLLLSLLPDYVDPSGIYNDVGLLMGT
LGQYESALDYLNKALEYRLEQGNPLLIAQVEHSLGDTYFKQGRYEESILYFEQAKAHLTP
ANYLFGLAYVHLGLGKAYIELNNFVEGDQHLFQALEYVNQHKDQHLQGLIYLSLAQAHFK
EQKYAQAIDYANQAVAISESASLPRIKAQAYLQLAKIAEAEQQYQEALSWYRQYAESELL
LRNTEQRKAFEALDLAKAELEQKRGVNFWRENYQALAEKYEMLKWQRVSLSLLVIVFALI
LPIAHYRRRKECDQNQQDSLHGVLSRTSGLERLTHIEACQQTEHVHLLALLDIDQLRQFN
ERHGYERGDIALQNTINTLLHQLRAKEFVCRLGDDEFLVVMPNCRRTLSETRLFVLHHAL
NGKTPTDAKSTVGLSVTLSYLAVESGLASFTHFYPKLDSALSIAKQSGNGGLIDAADPTN
ALLTACS