Protein Info for CSW01_06815 in Vibrio cholerae E7946 ATCC 55056

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 976 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 755 to 774 (20 residues), see Phobius details PF07494: Reg_prop" amino acids 46 to 68 (23 residues), 24.2 bits, see alignment (E = 3.6e-09) amino acids 291 to 313 (23 residues), 15.2 bits, see alignment (E = 3e-06) amino acids 418 to 441 (24 residues), 21.9 bits, see alignment (E = 2e-08) amino acids 462 to 482 (21 residues), 17.9 bits, see alignment (E = 3.9e-07) PF07495: Y_Y_Y" amino acids 684 to 745 (62 residues), 62.7 bits, see alignment 3.7e-21 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 804 to 965 (162 residues), 121.8 bits, see alignment E=1.2e-39 PF00990: GGDEF" amino acids 809 to 962 (154 residues), 115.1 bits, see alignment E=4.3e-37

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A0967)

Predicted SEED Role

"GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (976 amino acids)

>CSW01_06815 GGDEF domain-containing protein (Vibrio cholerae E7946 ATCC 55056)
MTGIRLLACCGVQICSVFLLIISSSAYAVVEHISDYFVETWTSTDGLPHNSINSIAQTRD
GYLWFATWEGVVRYNGINFQVFDRNPQTGMVDSGTRTLLPMDNNGLLVAGARGSITHRQS
YGWQSFRSAPSLVNGALIDDAQNLWLAIEGLGVVVRPYLGNNLYGPDRWLLTDASVYRLV
KNQHGVIFAATDKGLYRFNDWQASAMELPIGRYERINYISISLNQELVVATDQGVWINTE
EGFQSLFVPLEKEVVTLAEQDRAGNWWIGTVNRGIARLKNQQLQFLEPSRGLPYSRVLSW
YQDIEGSVWVGTNAGIMRLRDAPFININSDKGLVGDYVRTLLPLDDRRVMVGTSRGLSII
EEGLAHSALMPQVGARPSILSLAKADQQGEKVWVGTVQKGLLLWQNGQLRPVLDENNGLP
SSEVRAIVTDPQDNLWIGTSNGIVKRTPQGVLTTYNKDNSPLPDDYIMALAVDSEGKLWV
GSAVGVAYFDAQGKIRPVDLTKQEQAQYVFGFYMESDYVWMATDRGIVRYRLSDASVSLV
GRAAGLPIDKFFQMLRDSEGHVWLSSNRGVWKLNYDQMLAVADGMSTQLEFEHFDEGDGM
ATSQANGGTNPASASLPNGELLFATAKGVASIKVQRLQQLSELRLPVVLESVSFDSEIIN
PDQQYIAAAGTNRVSFGYVGLGFVMSERLQYRTKLEGFDRDWSYRGHNTQAEYTNLAPGK
YRFFVSARYPYGEWNDATFSYVFIIEPHWWQRKEVIVMAGMLFLALAVSLVMWRIRILKR
RELYLVEQVALQTQKLRLQAEKFERLSKEDDLTGLANRRAFDMYLKQAFSRLQNPDQQVS
IALLDIDHFKQINDRYSHIIGDQAIVAVSQELLGYVGDKTRVARWGGEEFTILYVGDPKQ
AWGYFEKLRCKIEQVDLSAVAPGLNVTVSIGFADAQQAESYETVLKLADHALLTAKKLGR
NRVVKSEEWQVKSGLH