Protein Info for CSW01_06795 in Vibrio cholerae E7946 ATCC 55056

Annotation: two-component system response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 379 PF00072: Response_reg" amino acids 11 to 121 (111 residues), 89.9 bits, see alignment E=1.9e-29 PF13487: HD_5" amino acids 163 to 343 (181 residues), 111 bits, see alignment E=8.3e-36 PF01966: HD" amino acids 175 to 311 (137 residues), 62.9 bits, see alignment E=5.3e-21

Best Hits

Swiss-Prot: 100% identical to CDPD2_VIBCH: Probable cyclic di-GMP phosphodiesterase VC_1348 (VC_1348) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K07814, putative two-component system response regulator (inferred from 100% identity to vco:VC0395_A0963)

Predicted SEED Role

"Response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (379 amino acids)

>CSW01_06795 two-component system response regulator (Vibrio cholerae E7946 ATCC 55056)
MSMEDLSQCTILIVDDSPDNIAFMSQGLAQYYRIKAARSGKVALEILAQYPIDLVLLDIV
MPEMSGYEVINQIKHNPHTEHIPVIFLTGKSNPEDEQLGFELGAVDYVFKPVSIPLLKSR
VHTHLQNKRSKDILLNQNDYLETEVLRRSGELDRMQDAVVFALASLAETRDPETGNHLLR
TQHYVKVLAQRLATTDKYRDVLSPTVIDTYFKAAPLHDIGKVGIPDNILLKPGKLTPDEF
TTMRNHALLGKLALEKAEKLSGACTALINVAKEIAMGHHEKWDGSGYPLGLKGDDIPLSA
RLMALADVYDALICRRVYKEPMSHEEAKAIILQGRGSHFDPMVIDAFLIEEQNFIDIAQK
FADEESAMVPIQLGQQASG