Protein Info for CSW01_06755 in Vibrio cholerae E7946 ATCC 55056

Annotation: acetate--CoA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF16177: ACAS_N
  • amino acids 4 to 56 (53 residues), 64.4 bits, 1e-21
• PF00501: AMP-binding
  • amino acids 65 to 447 (383 residues), 254 bits, E=3.4e-79
• PF13193: AMP-binding_C
  • amino acids 510 to 589 (80 residues), 96.7 bits, E=1.9e-31

Best Hits

Swiss-Prot: 60% identical to Y3568_PSEAE: Uncharacterized protein PA3568 (PA3568) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K01908, propionyl-CoA synthetase [EC: 6.2.1.17] (inferred from 100% identity to vco:VC0395_A0956)

MetaCyc: 58% identical to propionate--CoA ligase (Ruegeria pomeroyi DSS-3)
Propionate--CoA ligase. [EC: 6.2.1.17]

Predicted SEED Role

"Propionate--CoA ligase (EC 6.2.1.17)" in subsystem Methylcitrate cycle or Propionate-CoA to Succinate Module (EC 6.2.1.17)

MetaCyc Pathways

• 2-methylcitrate cycle I (5/5 steps found)
• 2-methylcitrate cycle II (5/6 steps found)
• acrylate degradation II (2/3 steps found)
• L-isoleucine biosynthesis IV (4/6 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (5/10 steps found)
• β-alanine biosynthesis II (1/6 steps found)

KEGG Metabolic Maps

• Propanoate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.17

Protein Sequence (625 amino acids)

>CSW01_06755 acetate--CoA ligase (Vibrio cholerae E7946 ATCC 55056)
MSAYQEQYQWAKEQPEAFWRKQAQQIDWFQPPQTILANDEHGIERWFPDGVLNTCWLALD
YHCEQGRGDHTALIYDSPVTGKKQRYSYSALRDSVAKIAGMLAAQGVSKGDRVIIYMPMI
PEAAMAMLACARLGAIHSVVFGGFAPNELAVRIEDAEPKVIMTASCGVEINKVIPYKPMV
DKAIMDSRWKPEKVLVYQRSECRAELTHARDLEWNTVVQSATPHGCVPVLATDPLYILYT
SGTTGKPKGVVRDNGGHAVALKYSMQIIYNMPQDGVFWAASDVGWVVGHSYIVYAPLIHG
CTTILYEGKPVRTPDPGAFWRVCQEYQVTALFSAPTAFRAIKKEDPNGDYLKKYDLSALT
TIFMAGERLDPPTLEWVQSKTGKPVIDHWWQTETGWAIAGNPTGLESMPIKAGSATKPIP
GYQVEILNELGENMPANQQGFVALKRPLPPSCLPTVWRNHDRFESGYLAQFPGYYVSGDG
GYLDDDGYLFIMGRIDDVINVAGHRLSTGEMEEIVGAHPAVAECAVIGVHDELKGQLPLG
LVVLKDGVKIDAQTLEQELVASVRNQIGAVACFKHAIVVERLPKTRSGKILRRIIRQIAD
GESYTIPSTIDDPMSLNELENLFQH