Protein Info for CSW01_06565 in Vibrio cholerae E7946 ATCC 55056

Annotation: L-serine ammonia-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00720: L-serine ammonia-lyase
  • amino acids 2 to 451 (450 residues), 764.3 bits, E=2.2e-234
• PF03315: SDH_beta
  • amino acids 3 to 155 (153 residues), 196.1 bits, E=4.4e-62
• PF03313: SDH_alpha
  • amino acids 183 to 448 (266 residues), 308.3 bits, E=5.3e-96

Best Hits

Swiss-Prot: 75% identical to SDHL_ECOLI: L-serine dehydratase 1 (sdaA) from Escherichia coli (strain K12)

KEGG orthology group: K01752, L-serine dehydratase [EC: 4.3.1.17] (inferred from 100% identity to vcj:VCD_003036)

MetaCyc: 75% identical to L-serine deaminase I (Escherichia coli K-12 substr. MG1655)
L-serine ammonia-lyase. [EC: 4.3.1.17]

Predicted SEED Role

No annotation

MetaCyc Pathways

• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• D-serine degradation (3/3 steps found)
• L-serine degradation (3/3 steps found)
• L-tryptophan degradation II (via pyruvate) (3/3 steps found)
• glycine degradation (3/3 steps found)
• L-methionine biosynthesis II (5/6 steps found)
• L-cysteine degradation II (2/3 steps found)
• glycine betaine degradation III (4/7 steps found)
• felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
• L-mimosine degradation (4/8 steps found)
• glycine betaine degradation I (4/8 steps found)
• glutathione-mediated detoxification I (3/8 steps found)
• purine nucleobases degradation II (anaerobic) (12/24 steps found)

KEGG Metabolic Maps

• Cysteine metabolism
• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.3.1.17

Use Curated BLAST to search for 4.3.1.17

Protein Sequence (453 amino acids)

>CSW01_06565 L-serine ammonia-lyase (Vibrio cholerae E7946 ATCC 55056)
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDELRSMGKLRDVTKITVDVYGSLSLTGKGH
HTDIAIIMGLAGNTPEKVDIDSIPSFIARVEETERLPVGMHCHTVSFPREGGMNFHRTNL
PLHENGMQIHAWINDEKIFSKTYYSIGGGFIVDEEHFGKENESLIQVPYAFRSAEELLNQ
CKESGLSISTLVMANEKAMHSDEEVRTYFANIWRTMRECMERGMNTEGILPGPLRVPRRA
AALRQQLLTSEKTTNDPMAVVDWVNMYAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYY
DKFIQTVTEKDYIRYFAASGAIGGLYKRNASISGAEVGCQGEVGVACSMAAAGLAELLGG
SPEQVCMAAEIAMEHNLGLTCDPVAGQVQVPCIERNGIAAVKAINSTRMALRRSSAPRVS
LDKVIETMLETGKDMNAKYRETSQGGLAIKVIC