Protein Info for CSW01_06540 in Vibrio cholerae E7946 ATCC 55056

Annotation: metal-dependent phosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 492 transmembrane" amino acids 15 to 35 (21 residues), see Phobius details amino acids 50 to 68 (19 residues), see Phobius details amino acids 80 to 101 (22 residues), see Phobius details amino acids 113 to 130 (18 residues), see Phobius details amino acids 160 to 180 (21 residues), see Phobius details amino acids 206 to 224 (19 residues), see Phobius details PF20970: MASE10" amino acids 23 to 208 (186 residues), 242.5 bits, see alignment E=5.9e-76 PF00672: HAMP" amino acids 236 to 275 (40 residues), 25.3 bits, see alignment 3.2e-09 PF01966: HD" amino acids 303 to 438 (136 residues), 62.9 bits, see alignment E=7e-21 PF13487: HD_5" amino acids 313 to 470 (158 residues), 106.8 bits, see alignment E=2.2e-34

Best Hits

Swiss-Prot: 100% identical to CDPD1_VIBCH: Cyclic di-GMP phosphodiesterase VC_1295 (VC_1295) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A0913)

Predicted SEED Role

"Response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (492 amino acids)

>CSW01_06540 metal-dependent phosphohydrolase (Vibrio cholerae E7946 ATCC 55056)
MTIWVLSLAMKNTIYHAPLTFGLYALAGVLFALYTSRVCPFLATLSTREIATQVGAVFIL
AWLIRHTLLRQHIWARKQQFIQLDTALLFAMSLPLALYYNLQYQFTLDSNLKVLFGMTLF
GFFTGALLQLSSKLRTLRQMPQSQNLALSSDERRSLVKQLIGLIVLLISTLTVMLSMVAI
KDIHWLENNPARLLDGSGKISIVKEFAFLSLVLGGYITAILVLWSRMMKEILDHQERSLQ
AVTQGNLQVRLPVYSNDELGNVAMLTNQMLDSLEATQNEVKTTRDVAIVSLSALAESRDN
ETGAHILRTQEYVKALAEYLAAFPQYSTLLTPAYIELLYKSAPLHDVGKVGIPDSVLLKP
GKLTDEEFTVMKEHPRIGAQALAIAERHLGTSSFLAIAKEIALTHHEKWDGTGYPAQLQG
EAIPLSGRLMALADVYDALISARVYKPAFSHDKAKAIIVEGSGHHFDPAVVEAFLAVEEK
FVAIAAHFKDAA