Protein Info for CSW01_06465 in Vibrio cholerae E7946 ATCC 55056

Annotation: BCCT family transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 540 transmembrane" amino acids 39 to 57 (19 residues), see Phobius details amino acids 79 to 98 (20 residues), see Phobius details amino acids 117 to 138 (22 residues), see Phobius details amino acids 175 to 193 (19 residues), see Phobius details amino acids 214 to 238 (25 residues), see Phobius details amino acids 258 to 278 (21 residues), see Phobius details amino acids 290 to 313 (24 residues), see Phobius details amino acids 344 to 362 (19 residues), see Phobius details amino acids 374 to 397 (24 residues), see Phobius details amino acids 427 to 448 (22 residues), see Phobius details amino acids 471 to 491 (21 residues), see Phobius details amino acids 497 to 521 (25 residues), see Phobius details PF02028: BCCT" amino acids 39 to 527 (489 residues), 586.6 bits, see alignment E=1.7e-180 TIGR00842: transporter, betaine/carnitine/choline transporter (BCCT) family" amino acids 79 to 527 (449 residues), 460.5 bits, see alignment E=2.8e-142

Best Hits

Swiss-Prot: 82% identical to BCCT3_VIBPA: Glycine betaine transporter 1 (VP1905) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K03451, betaine/carnitine transporter, BCCT family (inferred from 100% identity to vch:VC1279)

Predicted SEED Role

"High-affinity choline uptake protein BetT" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (540 amino acids)

>CSW01_06465 BCCT family transporter (Vibrio cholerae E7946 ATCC 55056)
MTQRGYMTKEIDKYSIDNTDYTVGQDNVQKWGFDVHNPVFGISAGLIAAFLLLTVLVDAH
QAKIGLDTVKQSIIASFDWLFIWSGNLFLLFCVGLVISPFGKIRLGGQAAKADHSFLSWL
AMLFAAGMGIGLMFWSVAEPVAYYTGWYETPLGVEANTPQAAQLAMGATMFHWGLHPWAI
YGVVALSLAFFCYNKGLPLSMRSVFYPLLGDRAWGWAGHVVDILAVLATLFGLATSLGLG
AQQAASGIHHVFGFESGIGLQIAVICVVTGLATLSVVRGIDGGVKVISNINMIVAFLLLA
LVAVIGYSVTLTSIPTTLMAYLQNLIPLSNPHGREDEVWFQGWTVFYWAWWISWSPFVGM
FIARVSKGRTIREFIVAVLLIPTLVTLVWMSVFGGLAVDQVINEIGVLGQNGLTDVSLAM
FQMFDSLVFGKVLSVIAVVLVLVFFITSSDSGSLVIDSITSGGKLDSPVLQRVFWAVLEG
AVAVALLWIGGTEAVQALQAGVISTALPFTVILLLMCVSLWKGLKTEPEFMASSKRLHQS