Protein Info for CSW01_06455 in Vibrio cholerae E7946 ATCC 55056

Annotation: DNA-binding response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 216 PF00072: Response_reg" amino acids 11 to 123 (113 residues), 100.5 bits, see alignment E=9.4e-33 PF00196: GerE" amino acids 154 to 209 (56 residues), 69.6 bits, see alignment E=2.1e-23 PF08281: Sigma70_r4_2" amino acids 155 to 195 (41 residues), 26.2 bits, see alignment 7.8e-10

Best Hits

Swiss-Prot: 44% identical to MCTR_RHIL3: Transcriptional regulatory protein MctR (mctR) from Rhizobium leguminosarum bv. viciae (strain 3841)

KEGG orthology group: K07684, two-component system, NarL family, nitrate/nitrite response regulator NarL (inferred from 100% identity to vco:VC0395_A0896)

Predicted SEED Role

"DNA-binding response regulator, LuxR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (216 amino acids)

>CSW01_06455 DNA-binding response regulator (Vibrio cholerae E7946 ATCC 55056)
MEVFMDKPIRVVMVDDHQVVLDGFIARLEQEPEIEVVATASNGLEALELVKLHQPDVVLM
DVSMPIMNGIEATRLIKEEVPHTKVLMLTMHDNREYIMQVMQAGAMGYMLKEISALKMVQ
AIKTVHQGATYFCESTTSTLFSQEILPVANKPNPLSRREEAILRMVAQGCSSKKIATLLN
ISYRTVETHRQNIKHKLDIHSTAELAQYALQHGLLE