Protein Info for CSW01_06280 in Vibrio cholerae E7946 ATCC 55056

Annotation: succinylglutamate desuccinylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF24827: AstE_AspA_cat
  • amino acids 53 to 245 (193 residues), 188.3 bits, E=1.1e-59
• PF04952: AstE_AspA_hybrid
  • amino acids 258 to 329 (72 residues), 79.7 bits, E=1.3e-26

Best Hits

Swiss-Prot: 100% identical to ASTE_VIBCH: Succinylglutamate desuccinylase (astE) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K05526, succinylglutamate desuccinylase [EC: 3.5.1.96] (inferred from 99% identity to vco:VC0395_A0863)

Predicted SEED Role

"Succinylglutamate desuccinylase (EC 3.5.1.96)" in subsystem Arginine and Ornithine Degradation (EC 3.5.1.96)

MetaCyc Pathways

• L-arginine degradation II (AST pathway) (4/5 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.96

Protein Sequence (342 amino acids)

>CSW01_06280 succinylglutamate desuccinylase (Vibrio cholerae E7946 ATCC 55056)
MTKSLFRQSFLFDSLDLDHPMVAQTVRTEQGVTLKLHQRGVLEVIPAQTDAATKNMVISC
GIHGDETAPMELLDKWIDDIVSGFQPVAERCLFIMAHPQATVRHVRFIEQNLNRLFDDKP
HTPSTELAIADNLKVLLRQFFANTDEHSRWHLDLHCAIRGSKHYSFAVSPKARHPVRSRS
LMQFIEQAHIEAVMLSNAPSSTFSWYSAEHYAAQALTLELGQVARLGENLLDRLLAFDLA
MRDLISRHKPEHLPRKSVMYRVSRTIVRLHDDFDFRFSDDVENFTAFMHGEVFGHDGDKP
LMAKNEGEAIVFPNRKVAIGQRAALMVCKVNTRYEDDQLVYD