Protein Info for CSW01_06250 in Vibrio cholerae E7946 ATCC 55056

Annotation: peptide-methionine (R)-S-oxide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00357: methionine-R-sulfoxide reductase
  • amino acids 24 to 144 (121 residues), 169.9 bits, E=1.4e-54
• PF01641: SelR
  • amino acids 28 to 144 (117 residues), 163.7 bits, E=8.7e-53

Best Hits

Swiss-Prot: 54% identical to MSRB_AGRFC: Peptide methionine sulfoxide reductase MsrB (msrB) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K07305, peptide-methionine (R)-S-oxide reductase [EC: 1.8.4.12] (inferred from 100% identity to vcj:VCD_003113)

MetaCyc: 49% identical to methionine sulfoxide reductase B (Escherichia coli K-12 substr. MG1655)
L-methionine (R)-S-oxide reductase. [EC: 1.8.4.14]; Peptide-methionine (R)-S-oxide reductase. [EC: 1.8.4.14, 1.8.4.12]

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)" (EC 1.8.4.12)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.4.12

Use Curated BLAST to search for 1.8.4.12 or 1.8.4.14

Protein Sequence (148 amino acids)

>CSW01_06250 peptide-methionine (R)-S-oxide reductase (Vibrio cholerae E7946 ATCC 55056)
MLNWQQVLDFANQGNPKPEREVTRSDEEWRTLLDEQQYYVMRQHGTERAFSNAMCELFEP
GLYQCAGCQTLLFDSATKFDSGTGWPSFSQPVKFNAISYHMDQSLARARVEVRCNTCESH
LGHVFPDGPPPSGLRYCINSVAVNKLSA