Protein Info for CSW01_06125 in Vibrio cholerae E7946 ATCC 55056

Annotation: diguanylate phosphodiesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 704 transmembrane" amino acids 39 to 62 (24 residues), see Phobius details amino acids 80 to 101 (22 residues), see Phobius details amino acids 107 to 124 (18 residues), see Phobius details amino acids 131 to 152 (22 residues), see Phobius details amino acids 172 to 194 (23 residues), see Phobius details amino acids 214 to 237 (24 residues), see Phobius details amino acids 270 to 294 (25 residues), see Phobius details amino acids 301 to 324 (24 residues), see Phobius details amino acids 330 to 349 (20 residues), see Phobius details amino acids 354 to 373 (20 residues), see Phobius details amino acids 380 to 401 (22 residues), see Phobius details PF02378: PTS_EIIC" amino acids 36 to 338 (303 residues), 74.3 bits, see alignment E=9.5e-25 PF00563: EAL" amino acids 452 to 679 (228 residues), 218.3 bits, see alignment E=1e-68

Best Hits

KEGG orthology group: None (inferred from 100% identity to vcm:VCM66_1166)

Predicted SEED Role

"FOG: EAL domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (704 amino acids)

>CSW01_06125 diguanylate phosphodiesterase (Vibrio cholerae E7946 ATCC 55056)
MSLFSMLSFNKYLPTVRKNELTKVSQYLVSAMHSIREGMVWLIPCLMISSFVLFIASMGE
LFSGGRPEWVLILYRANQVIAETFPYLMTATISYLLAMHWHLPRPPIALLSIIYLVVSSA
SVSAENNLPTFQIITALITPIYAIPLIAWLMRYPVLHLTRSNSAGSIVRESLNLVLPAAL
TAMVVVGINLILFGPITRQIFASLMHFDYANDPYSFGLTFASLNSLLWFFGIHGYYALLP
LVELLQEASRLSESYFLIGETAPYPMNLSFMGTFVFIGGSGATFSLALAILLFGKQKNIR
LLAIASLPIGLINVNEIFLFGLPLILNPRLFFPFLLAPMVNVVVSLWAVESGWVAYPSVS
VPFNSPIFLNAWIATSGDWNGLLLQLVNIVLGCLLYLPSVLRLNEQYGQQTIRIPSLDTM
YTRRQEEAAHLQDDPIALAQKREREQLKVEQQLQMMSSKEFCLEYQPQVCHRTGQVIGCE
ALIRAKDQQDNILSPATFLPSLAKAGLMKEMDLWVVKQATSDVRKLTNVGVYVPVSINLT
AETLMDLTVMAQIEEIIRSVAGLIHIELTEESLLADEQRLTWVFNQLHQLGVKIYIDDFG
TGYSSLSYLHRFDVDGIKIDRSFVLALVSEKGRKVFANLQLVAHSLELETIIEGVETQEQ
LDAMGDEYPFSVQGWFYSKSLNRGDFVEFVQRRNASKTVPVEAQ