Protein Info for CSW01_06060 in Vibrio cholerae E7946 ATCC 55056
Annotation: FAD-binding oxidoreductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 61% identical to YDIJ_ECOLI: Uncharacterized protein YdiJ (ydiJ) from Escherichia coli (strain K12)
MetaCyc: 61% identical to D-2-hydroxyglutarate dehydrogenase (Escherichia coli K-12 substr. MG1655)
RXN-14932 [EC: 1.1.99.39]
Predicted SEED Role
"Glycolate dehydrogenase (EC 1.1.99.14), subunit GlcD" in subsystem Glycolate, glyoxylate interconversions or Photorespiration (oxidative C2 cycle) (EC 1.1.99.14)
MetaCyc Pathways
- photorespiration II (8/10 steps found)
- glycolate and glyoxylate degradation II (2/2 steps found)
- photorespiration I (7/9 steps found)
- photorespiration III (7/9 steps found)
- glycolate and glyoxylate degradation I (3/4 steps found)
- superpathway of glycol metabolism and degradation (5/7 steps found)
- glycolate and glyoxylate degradation III (1/3 steps found)
- L-lysine degradation V (3/9 steps found)
- superpathway of L-lysine degradation (9/43 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.1.99.14 or 1.1.99.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (1021 amino acids)
>CSW01_06060 FAD-binding oxidoreductase (Vibrio cholerae E7946 ATCC 55056) MDQRSRGRKQMLPRLHHQSDVDPVVLTFLHELKTAGFTGDIETQYSSRLAVATDNSVYQQ LPQAVVHPKSTADVVLIGKISSKPEFERVTFSPRGGGTGTNGQSLTKGVVVDLSRHMNRI LEINPQEGWVRVQAGVIKDQLNDAVRPHGFFFSPDLSTSNRATLGGMVNTDASGQGSLQY GKTSDHVLSLQAVFADGSLLETDLSQGLPAPNTFAAQAMQVTEQVCRTKRKQIVAKFPPL NRFLTGYDLKNALNEAEDRFDITRVLCGAEGSLAFITEAKLNLTPIPKARTLVNVKYDSF DSALRNAPLMVEAKALSVETVDSKVLNLAKEDIIWHSVKDLLTDVPGKEMQGINMVEYAG QDSAQINQQVAQLTARLDEMMANQQAGIIGYQVCSDLASINRIYNMRKKAVGLLGAAKGR AKPVAFTEDTCVPPENLADFIVEFRALLDSKNLAYGMFGHVDAGVLHVRPALDLCDPKQE LLMREISDQVVKLVAKYGGLMWGEHGKGYRSEYGPEFFGEELFTELRRVKAAFDPHNKMN PGKICTPLDTPFELVKVSDTKRGFYDRQIDVKVRDSFKQAMECNGNGLCFNYETSSPMCP SMKVTADRRHSPKGRAGLVREWLRQLTEQGIDILDLEKATLESSPTIKSMLDRVRHAFSK DKEYDFSHEVYEAMNGCLACKACASQCPIKVDVPSFRSRFLNIYHSRYPRPVKDYLVANI ETLLPVMAKAPQLVNSVLAQSSVQKLTAKTVGYVDAPLLSVPTLAQRLRRHPVVLFDMQR LAGLSQEEREQHVLIVQDPFTSYYDADVVEDFVALLLKLGKKPVLLPFKPNGKAQHIKGF LRQFRSTAANTAAFLTQVADLNIPLVGVDPALVLCYRDEYVEILGKERGEFSVLTVHEWL KPRLSQFTPQVTDAQPWYLLAHCTEKTKLPNAEKEWVEIFRHFGTQLNAVAVGCCGMAGT FGHEVDKLTMSRDIYDLSWQPALASLPKERCLVTGYSCRSQVKRFEQIKPKHPLQALLHL L