Protein Info for CSW01_05670 in Vibrio cholerae E7946 ATCC 55056

Annotation: protease HtpX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 287 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 37 to 57 (21 residues), see Phobius details amino acids 161 to 179 (19 residues), see Phobius details amino acids 191 to 215 (25 residues), see Phobius details PF01435: Peptidase_M48" amino acids 79 to 286 (208 residues), 135.3 bits, see alignment E=1.2e-43

Best Hits

Swiss-Prot: 100% identical to HTPX_VIBCM: Protease HtpX (htpX) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K03799, heat shock protein HtpX [EC: 3.4.24.-] (inferred from 100% identity to vcm:VCM66_1073)

Predicted SEED Role

"Probable protease htpX homolog (EC 3.4.24.-)" (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (287 amino acids)

>CSW01_05670 protease HtpX (Vibrio cholerae E7946 ATCC 55056)
MKRILLFLATNLAVVLVLSVVLNIVYAVTGMQPGSLSGLLVMAAVFGFGGAFISLLMSKS
MALRSVGGVVIDTPRNEMEHWLLETVRRQANQAGIGMPTVAIYDAPDMNAFATGAKRDDS
LVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMVTMTLMQGVVNTFVIFLSRFIANIVAS
RDSEEGEGSNMMVYFGVSMVLELVFGFLASFITMWYSRHREFHADAGAAQLVGKHKMIAA
LERLKMGQESHLEGSMMAFGITGKRSLSELMMTHPPLEKRIAALRNM