Protein Info for CSW01_05655 in Vibrio cholerae E7946 ATCC 55056

Annotation: malonyl-[acyl-carrier protein] O-methyltransferase BioC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 267 PF01209: Ubie_methyltran" amino acids 18 to 154 (137 residues), 57.1 bits, see alignment E=1e-18 TIGR02072: malonyl-acyl carrier protein O-methyltransferase BioC" amino acids 21 to 266 (246 residues), 216 bits, see alignment E=3.5e-68 PF13489: Methyltransf_23" amino acids 38 to 193 (156 residues), 65 bits, see alignment E=4.1e-21 PF05175: MTS" amino acids 38 to 105 (68 residues), 29 bits, see alignment E=4.3e-10 PF01728: FtsJ" amino acids 45 to 92 (48 residues), 25.1 bits, see alignment 8.2e-09 PF08003: Methyltransf_9" amino acids 47 to 153 (107 residues), 26.1 bits, see alignment E=2.3e-09 PF07021: MetW" amino acids 52 to 141 (90 residues), 23 bits, see alignment E=3.1e-08 PF13847: Methyltransf_31" amino acids 52 to 151 (100 residues), 71.5 bits, see alignment E=3.5e-23 PF03141: Methyltransf_29" amino acids 55 to 151 (97 residues), 27.9 bits, see alignment E=5.2e-10 PF13649: Methyltransf_25" amino acids 56 to 146 (91 residues), 85.3 bits, see alignment E=2.1e-27 PF08241: Methyltransf_11" amino acids 57 to 149 (93 residues), 98.5 bits, see alignment E=1.6e-31 PF08242: Methyltransf_12" amino acids 57 to 146 (90 residues), 52.3 bits, see alignment E=4.3e-17

Best Hits

Swiss-Prot: 46% identical to BIOC_SERMA: Malonyl-[acyl-carrier protein] O-methyltransferase (bioC) from Serratia marcescens

KEGG orthology group: K02169, biotin synthesis protein BioC (inferred from 100% identity to vcj:VCD_003228)

MetaCyc: 45% identical to malonyl-acyl carrier protein methyltransferase (Escherichia coli K-12 substr. MG1655)
RXN-11475 [EC: 2.1.1.197]

Predicted SEED Role

"Biotin synthesis protein BioC"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.197

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (267 amino acids)

>CSW01_05655 malonyl-[acyl-carrier protein] O-methyltransferase BioC (Vibrio cholerae E7946 ATCC 55056)
MSMTATELCVELKDKSAIAQAFGKAAAHYDQHAAFQRDVGLRLLQKMPSCLKGLRVLDLG
CGTGYFSALLRERGAQVVCADISHAMLEQAKQRCGDEGMSYQLADAEQLPFASACFDMVF
SSLALQWCEDLSLPLSEIRRVLKPHGQAFLSTLLDGSLFELEQAWRSVDHHRHINQFISI
NQVKIALAQAGCSQHHLDLAAITVWYEAAFMLMRDLKGIGANHVSGRSTGLISRRTLAKV
ELAYQSFRNQQGLVPATYQVCLGVIHR