Protein Info for CSW01_05490 in Vibrio cholerae E7946 ATCC 55056

Annotation: L-threonylcarbamoyladenylate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 329 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family" amino acids 20 to 213 (194 residues), 192 bits, see alignment E=3.4e-61 PF01300: Sua5_yciO_yrdC" amino acids 28 to 203 (176 residues), 202.4 bits, see alignment E=4.3e-64 PF03481: Sua5_C" amino acids 205 to 329 (125 residues), 74.5 bits, see alignment E=1.3e-24

Best Hits

KEGG orthology group: K07566, putative translation factor (inferred from 100% identity to vcj:VCD_003261)

Predicted SEED Role

"TsaC protein (YrdC-Sua5 domains) required for threonylcarbamoyladenosine t(6)A37 modification in tRNA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (329 amino acids)

>CSW01_05490 L-threonylcarbamoyladenylate synthase (Vibrio cholerae E7946 ATCC 55056)
MPNHGDFLLNTQQLSAMTPADIECAAQLLKQGQLVAIPTETVYGLAADATQPEAVKQIFS
AKGRPANHPLIVHLGSAEQLSEWATDIAPEAYQLAEAFWPGPLTLLLPKAKQVSPVVTGG
LESVGIRVPAHPVLLDILKTHRLAVAAPSANPYKKLSPTSAQQVLDGLNGRLAAVLDGGE
CQHGLESTIVDLTSKPFRVLRAGPITASELSAVLGQEVLQPQVHQVAVPGNVDSHYQPKT
RLRVIDDLARELATQSDELRIALLNLSALQASEQRLLKPMPQEAKAYGQALYRSLAEVDK
WGVDEIWLERPPQGEAWLAVHDRLRRAAS