Protein Info for CSW01_05120 in Vibrio cholerae E7946 ATCC 55056

Annotation: sodium:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 441 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 52 to 72 (21 residues), see Phobius details amino acids 93 to 113 (21 residues), see Phobius details amino acids 119 to 138 (20 residues), see Phobius details amino acids 147 to 172 (26 residues), see Phobius details amino acids 194 to 215 (22 residues), see Phobius details amino acids 239 to 256 (18 residues), see Phobius details amino acids 262 to 280 (19 residues), see Phobius details amino acids 292 to 313 (22 residues), see Phobius details amino acids 333 to 352 (20 residues), see Phobius details amino acids 363 to 388 (26 residues), see Phobius details amino acids 423 to 440 (18 residues), see Phobius details PF13726: Na_H_antiport_2" amino acids 2 to 87 (86 residues), 121.1 bits, see alignment E=3.6e-39 PF02447: GntP_permease" amino acids 4 to 218 (215 residues), 23.3 bits, see alignment E=5.2e-09 PF03553: Na_H_antiporter" amino acids 150 to 435 (286 residues), 282.6 bits, see alignment E=7.7e-88 PF06808: DctM" amino acids 194 to 394 (201 residues), 30.6 bits, see alignment E=3.3e-11

Best Hits

Swiss-Prot: 88% identical to Y2115_VIBPA: Uncharacterized membrane protein VP2115 (VP2115) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K07084, (no description) (inferred from 100% identity to vco:VC0395_A0526)

Predicted SEED Role

"Histidine permease YuiF"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (441 amino acids)

>CSW01_05120 sodium:proton antiporter (Vibrio cholerae E7946 ATCC 55056)
MNPVVISVCVMLLLALMRVNVVVALTFSAVVGGLVAGMSLNETVAAFESGLGGGATIALS
YAMLGTFAVAISKSGITDLLAQSVIRRIHGQESHAASTGLKYLVLISLLLMAMASQNVIP
VHIAFIPILIPPLLSVFAKLKLDRRLVACVLTFGLITPYMVLPVGFGGIFLNNILLKNLH
ENGLESITASQVPTAMILPAAGMIFGLLLAVLFSYRKPREYQETELTVVQQESSSINKQH
IAIAGVGIVAALAVQLLTGSMIIGALAGFMVFTFGGVIAWKETHDVFTRGVHMMAMIGFI
MISAAGFAAVMKATGGVETLVTSLSTSIGDNKALAALLMLVVGLLVTMGIGSSFSTIPII
ATIYVPLCLSFGFSPMATVALVGTAAALGDAGSPASDSTLGPTSGLNADGQHEHIWETVV
PTFIHYNLPLIVFGWIAAMVL