Protein Info for CSW01_05030 in Vibrio cholerae E7946 ATCC 55056

Annotation: molecular chaperone HtpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 635 PF02518: HATPase_c" amino acids 34 to 187 (154 residues), 31.6 bits, see alignment E=2.9e-11 PF13589: HATPase_c_3" amino acids 35 to 175 (141 residues), 41.7 bits, see alignment E=1.7e-14 PF00183: HSP90" amino acids 227 to 632 (406 residues), 429.9 bits, see alignment E=2.7e-132

Best Hits

Swiss-Prot: 100% identical to HTPG_VIBCH: Chaperone protein HtpG (htpG) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 100% identity to vcm:VCM66_0941)

MetaCyc: 70% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (635 amino acids)

>CSW01_05030 molecular chaperone HtpG (Vibrio cholerae E7946 ATCC 55056)
MSETATTNKETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAVDKLRFQALSHPD
LYQGDAELGVKLSFDKDKNTLTISDNGIGMTRDEVIENLGTIAKSGTAEFFSKLSQEQSK
NSQLIGQFGVGFYSAFIVADAVTVRTRAAGSAPADAVQWYSKGEGEYTVETINKESRGTD
IILHLREEGKEFLSEWRLRDVISKYSDHIGIPVYIQTSVMDEEGKATEETKWEQINKAQA
LWTRAKSEVTDEEYKEFYKHVSHDFADPLVWSHNKVEGKNDYTSLLYIPAKAPWDLFNRE
HKHGLKLYVQRVFIMDDAAQFMPSYLRFVRGLIDSNDLPLNVSREILQDNKITQSLRQAC
TKRVLTMLERMASNDADNYQKFWKEFGLVMKEGPAEDFANREKIASLLRFASTHIDSAEQ
TISLASYVERMKEGQDKIYYLTADSYTAAKNSPHLEQFKSKGIEVILMFDRIDEWLMNYL
PEFEGKAFQSITKAGLDLSQFEDEAEKEKHKETEEQFKSVVERLKGYLGSRVKEVRTTFK
LANTPAVVVTDDYEMGTQMAKLLAAAGQPVPEVKYILEVNPEHALVKRMADEADEQTFGR
WAEVLLGQAMLAERGSMEDPSQFLGAVNQLLAPSH