Protein Info for CSW01_04700 in Vibrio cholerae E7946 ATCC 55056

Annotation: low molecular weight phosphotyrosine protein phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 166 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF01451: LMWPc" amino acids 8 to 148 (141 residues), 97.2 bits, see alignment E=5.3e-32

Best Hits

KEGG orthology group: K01104, protein-tyrosine phosphatase [EC: 3.1.3.48] (inferred from 100% identity to vcm:VCM66_0873)

Predicted SEED Role

"Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48)" in subsystem LMPTP YfkJ cluster or LMPTP YwlE cluster (EC 3.1.3.48)

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.48

Use Curated BLAST to search for 3.1.3.48

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (166 amino acids)

>CSW01_04700 low molecular weight phosphotyrosine protein phosphatase (Vibrio cholerae E7946 ATCC 55056)
MKVKGLSVLVVCTGNLCRSPMAEIILRDKIRQKRLNIQVRSAGTLKTGKTMPDDKALQAL
QDYGYHPMVNPVQQVTQQDFIEHDFIYAMDRTNLADLLDICPAEHKNKLALFLSKANRQE
KEVPDPYRRSSEFFQRTALLIESGAVALVDSWQEQGINACNENLSQ