Protein Info for CSW01_04660 in Vibrio cholerae E7946 ATCC 55056

Annotation: PTS trehalose transporter subunit IIBC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 478 transmembrane" amino acids 114 to 135 (22 residues), see Phobius details amino acids 155 to 180 (26 residues), see Phobius details amino acids 190 to 211 (22 residues), see Phobius details amino acids 231 to 248 (18 residues), see Phobius details amino acids 259 to 281 (23 residues), see Phobius details amino acids 304 to 324 (21 residues), see Phobius details amino acids 344 to 365 (22 residues), see Phobius details amino acids 403 to 426 (24 residues), see Phobius details amino acids 442 to 464 (23 residues), see Phobius details TIGR01992: PTS system, trehalose-specific IIBC component" amino acids 10 to 465 (456 residues), 677.5 bits, see alignment E=1e-207 PF00367: PTS_EIIB" amino acids 15 to 47 (33 residues), 46.9 bits, see alignment (E = 1.5e-16) TIGR00826: PTS system, glucose-like IIB component" amino acids 34 to 115 (82 residues), 52.4 bits, see alignment E=5.3e-18 PF02378: PTS_EIIC" amino acids 116 to 408 (293 residues), 132.5 bits, see alignment E=1.8e-42

Best Hits

Swiss-Prot: 68% identical to PTTBC_ECOLI: PTS system trehalose-specific EIIBC component (treB) from Escherichia coli (strain K12)

KEGG orthology group: K02818, PTS system, trehalose-specific IIB component [EC: 2.7.1.69] K02819, PTS system, trehalose-specific IIC component (inferred from 100% identity to vco:VC0395_A0432)

MetaCyc: 68% identical to trehalose-specific PTS enzyme IIBC component (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-168 [EC: 2.7.1.201]

Predicted SEED Role

"PTS system, trehalose-specific IIB component (EC 2.7.1.69) / PTS system, trehalose-specific IIC component (EC 2.7.1.69)" in subsystem Trehalose Uptake and Utilization (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.201 or 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (478 amino acids)

>CSW01_04660 PTS trehalose transporter subunit IIBC (Vibrio cholerae E7946 ATCC 55056)
MDEDMSKIAKQDVTRLIELVGGESNIASVTHCLTRLRFVLNQPEQADKAGLEALSMVKGC
FTNAGQFQVVIGTEVDQVYKMLLEQTGKQAVSKDDAKVAARQNMNVLERGISHLAEIFVP
LLPAIITGGLILGFRNVIGDIRMFDGKTLTEISQFWASVHAFLWLIGEAIFFFLPVGVCW
STVKKLGGTPILGITLGVTLVSPQLMNAYLIGKEVPEVWDFGLFAIEKVGYQAQVIPAIL
AGVALAFIENNLRRVVPSYLYLVVVPFVSIIVSVVLAHAFIGPFGRVIGDGVAFAAKAAM
TGDFAVIGSTLFGFMYAPLVITGIHHTTNAVDLQLMQELGGTPIWPLIALSNIAQASAVV
GIIIISKKQGERDISVPAAISAYLGVTEPAMYGINLKYKFPMLSAMIGSALAAAVCGSAG
VMANGIGVGGLPGILSIQPQFWSIYLVAMLIAILVPAALTLLMYKRAQSSGKLAVSAA