Protein Info for CSW01_04455 in Vibrio cholerae E7946 ATCC 55056

Annotation: tRNA adenosine(34) deaminase TadA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 193 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00383: dCMP_cyt_deam_1" amino acids 27 to 125 (99 residues), 110.3 bits, see alignment E=6e-36 PF14437: MafB19-deam" amino acids 27 to 173 (147 residues), 132.3 bits, see alignment E=1.8e-42 PF18750: SNAD4" amino acids 64 to 115 (52 residues), 27.1 bits, see alignment E=5.8e-10

Best Hits

Swiss-Prot: 53% identical to TADA_ECOLI: tRNA-specific adenosine deaminase (tadA) from Escherichia coli (strain K12)

KEGG orthology group: K11991, tRNA-specific adenosine deaminase [EC: 3.5.4.-] (inferred from 100% identity to vco:VC0395_A0390)

MetaCyc: 53% identical to tRNA adenosine34 deaminase (Escherichia coli K-12 substr. MG1655)
3.5.4.-

Predicted SEED Role

"tRNA-specific adenosine-34 deaminase (EC 3.5.4.-)" in subsystem tRNA processing (EC 3.5.4.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.-

Use Curated BLAST to search for 3.5.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (193 amino acids)

>CSW01_04455 tRNA adenosine(34) deaminase TadA (Vibrio cholerae E7946 ATCC 55056)
MSAISARITVFKNPWSVILSASLFSAQDEQFMRRAIVLAAQAEAQGEVPVGAVLVRDGEI
IAEGWNGSITNHDATAHAEIEVIRKAGKALSNYRLLDTTLYVTLEPCPMCAGALLHSRVK
RIVYGAPDLKAGAAGTVMDLFSSQAAYHYATVEKGLLEEECRAQLQAFFQRRRKEIKAKR
DAERKNAERKNER