Protein Info for CSW01_04310 in Vibrio cholerae E7946 ATCC 55056

Annotation: pilus assembly protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 338 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details

Best Hits

Swiss-Prot: 99% identical to TCPF_VIBC3: Toxin coregulated pilus biosynthesis protein F (tcpF) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K10935, toxin co-regulated pilus biosynthesis protein F (inferred from 99% identity to vco:VC0395_A0362)

Predicted SEED Role

"Toxin co-regulated pilus biosynthesis protein F, putative outer membrane channel for TcpA extrusion" in subsystem Toxin co-regulated pilus or Vibrio pathogenicity island

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (338 amino acids)

>CSW01_04310 pilus assembly protein (Vibrio cholerae E7946 ATCC 55056)
MRYKKTLMLSIMITSFNSFAFNDNYSSTSTVYATSNEATDSRGSEHLRYPYLECIKIGMS
RDYLENCVKVSFPTSQDMFYDAYPSTESDGAKTRTKEDFSARLLAGDYDSLQKLYIDFYL
AQTTFDWEIPTRDQIETLVNYANEGKLSTALNQEYITGRFLTKENGRYDIVNVGGVPDNT
PVKLPAIVSKRGLMGTTSVVNAIPNEIYPHIKVYEGTLSRLKPGGAMIAVLEYDVSELSK
HGYTNLWDVQFKVLVGVPHAETGVIYDPVYEETVKPYQPSGNLTGKKLYNVSTNDMHNGY
KWSNTMFSNSNYKTQILLTKGDGSGVKLYSKAYSENFK