Protein Info for CSW01_04245 in Vibrio cholerae E7946 ATCC 55056

Annotation: 2-Cys peroxiredoxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08534: Redoxin
  • amino acids 18 to 161 (144 residues), 114.3 bits, E=4.5e-37
• PF00578: AhpC-TSA
  • amino acids 19 to 144 (126 residues), 48.7 bits, E=7.4e-17

Best Hits

Swiss-Prot: 100% identical to TPX_VIBCH: Thiol peroxidase (tpx) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K11065, thiol peroxidase, atypical 2-Cys peroxiredoxin [EC: 1.11.1.15] (inferred from 99% identity to vco:VC0395_A0349)

MetaCyc: 48% identical to lipid hydroperoxide peroxidase (Escherichia coli K-12 substr. MG1655)
1.11.1.15-RXN [EC: 1.11.1.24]

Predicted SEED Role

"Thiol peroxidase, Tpx-type (EC 1.11.1.15)" in subsystem Thioredoxin-disulfide reductase (EC 1.11.1.15)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.24

Protein Sequence (164 amino acids)

>CSW01_04245 2-Cys peroxiredoxin (Vibrio cholerae E7946 ATCC 55056)
MTVTFQNNPVSISGSFPKVGDRLPSFTLCGADLNDLSNEDFKGKKIVMSIFPSIDTPVCS
KSVKVLQNALMTRNDTVLLCVSADLPFAMSRFCTEHAVANVTNASFFREPAFTERFGVNL
NEGALRGLAARAVIVADEFGVITHSELVNEITNEPDYDRILMSL