Protein Info for CSW01_04230 in Vibrio cholerae E7946 ATCC 55056

Annotation: peptidase M66

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1013 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details PF00041: fn3" amino acids 68 to 130 (63 residues), 29.6 bits, see alignment 1e-10 PF10462: Peptidase_M66" amino acids 244 to 545 (302 residues), 320.5 bits, see alignment E=1.5e-99 PF12561: TagA" amino acids 571 to 822 (252 residues), 104.7 bits, see alignment E=4.8e-34

Best Hits

Swiss-Prot: 100% identical to TAGA_VIBCH: ToxR-activated gene A lipoprotein (tagA) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: None (inferred from 100% identity to vcj:VCD_003507)

Predicted SEED Role

"Lipoprotein, ToxR-activated gene, TagA" in subsystem Vibrio pathogenicity island

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1013 amino acids)

>CSW01_04230 peptidase M66 (Vibrio cholerae E7946 ATCC 55056)
MIFSKNVYEELVVVRYSLLMKVSFAILIFLVGCNENATSSNDQYLTDPDISEQTKKPSRP
IIDEKNKGVTDTSVTIEWDKIECEKNFSHYNVIVYRKDRIEDVITIRTRNNSVFIDDLKP
NSQYSIDVSSCLHSACSESAKIEFITLNEIDYYHTTEIEKNVYGSLEGEVRFVQTHVISP
EGRKNEPEIITGRDALILFKPSIKNSSSILMKIYSEDGLTSKVVMKSPSMLPKTDQPIDI
DENNKVVSYSNSYWSAEIPWNKMKSGMSLHFEDENGNLGIIESERIKFSAPSELIIQNID
LGMLYKPRGRNIVIKELERTAVDYFQKVPVSKLIFSDYTPIHFEKITLPNGTVYTEKSAD
IGGWHQGDMREAVGKALVSTGINNANLGIVASSGYSQQYNRLTNHITAHTNIGYYNNGVV
VHGGSGGGGIVTLENTLHNEWSHELGHNYGLGHYVAGGTSHGPDTSWGWDGYYKRFIANF
DWKRSPQSNIRPDNQEVVKPFMDKYTYLWDAMSGGYDHQNGIISRYTLHHPYVARIIQDW
LKNGAVVINNDYMVWDELKNIYVYKGTNFKVPIKKGVPVVTILGVYDPDKINPSQLYPPT
YSNYGNIFDLEKPRSESSLKGWQYVKDVNYLDRVNTHWHTMLVNRKEEKICRFSYLSPKG
KKFEFLGYEDIENKICTGGRSIHYLEDGKKNPIESKYNDYFLLSIDGDGEISYVPDSTIG
ESKICSLKMSGTVYGAGFIKGNSCRQIDGVFMNGFQWAFTLNQSGVNSTYTWSNECVLKI
KDKDNNIESISIPNYRIEKNQSNKIHLNISREKPIIDINVYCGEHELTSIKVSDNPDIKL
LKGPIIVGQEHGYTSYEPKLPSGWFKHYDNFEPKNEINHELGKMRVNDNDEYICRFNFSD
SDREMKFVGYVSQLSESKYICTGGSEIYYKKNEINIELSSKENDFEWLSVRDKNLVGSKI
EFDNNKTLCVLDNRSFYGAGYLDENNRCTQDRQIHWSNGKQWLFSTYKTMTYH