Protein Info for CSW01_04020 in Vibrio cholerae E7946 ATCC 55056

Annotation: vibriobactin biosynthesis amide synthase VibH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 438 PF00668: Condensation" amino acids 5 to 416 (412 residues), 134.1 bits, see alignment E=3.1e-43

Best Hits

KEGG orthology group: K04778, vibriobactin synthetase (inferred from 100% identity to vcj:VCD_003551)

MetaCyc: 100% identical to VibH norspermidine-2,3-dihydroxybenzoate synthase (Vibrio cholerae)
RXN-10990

Predicted SEED Role

"Amide synthase component of siderophore synthetase" in subsystem Iron acquisition in Vibrio

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (438 amino acids)

>CSW01_04020 vibriobactin biosynthesis amide synthase VibH (Vibrio cholerae E7946 ATCC 55056)
MSMLLAQKPFWQRHLAYPHINLDTVAHSLRLTGPLDTTLLLRALHLTVSEIDLFRARFSA
QGELYWHPFSPPIDYQDLSIHLEAEPLAWRQIEQDLQRSSTLIDAPITSHQVYRLSHSEH
LIYTRAHHIVLDGYGMMLFEQRLSQHYQSLLSGQTPTAAFKPYQSYLEEEAAYLTSHRYW
QDKQFWQGYLREAPDLTLTSATYDPQLSHAVSLSYTLNSQLNHLLLKLANANQIGWPDAL
VALCALYLESAEPDAPWLWLPFMNRWGSVAANVPGLMVNSLPLLRLSAQQTSLGNYLKQS
GQAIRSLYLHGRYRIEQIEQDQGLNAEQSYFMSPFINILPFESPHFADCQTELKVLASGS
AEGINFTFRGSPQHELCLDITADLASYPQSHWQSHCERFPRFFEQLLARFQQVEQDVARL
LAEPAALAATTSTRAIAS