Protein Info for CSW01_04015 in Vibrio cholerae E7946 ATCC 55056

Annotation: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 262 signal peptide" amino acids 1 to 38 (38 residues), see Phobius details transmembrane" amino acids 111 to 130 (20 residues), see Phobius details PF23441: SDR" amino acids 6 to 259 (254 residues), 33.9 bits, see alignment E=4.6e-12 PF08659: KR" amino acids 11 to 169 (159 residues), 29.4 bits, see alignment E=1.5e-10 PF00106: adh_short" amino acids 11 to 202 (192 residues), 148.9 bits, see alignment E=2.5e-47 TIGR04316: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" amino acids 11 to 261 (251 residues), 370.9 bits, see alignment E=1.6e-115 PF13561: adh_short_C2" amino acids 15 to 259 (245 residues), 163.8 bits, see alignment E=1e-51

Best Hits

Swiss-Prot: 100% identical to VIBA_VIBCH: Vibriobactin-specific 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (vibA) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K00216, 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase [EC: 1.3.1.28] (inferred from 100% identity to vcm:VCM66_0732)

MetaCyc: 100% identical to vibriobactin-specific 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (Vibrio cholerae)
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase. [EC: 1.3.1.28]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.1.28

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (262 amino acids)

>CSW01_04015 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (Vibrio cholerae E7946 ATCC 55056)
MKDMSLVNSKVLLVGSARGIGFSVLEHLLQAGAQVMAADCEWQLLLEQSESLLGRYPDQL
TLKKLDLAEPEAVREQVNQWAEQVAGFDHLVCCAGILHVAPLHEMPMEQVSSIFTVNAFG
VLACMQGVASSMKARQQGSMVIIGSNAANTPRMSIGAYGASKAALHMLVKCIGMELAPYG
IRCNLVSPGSTRTAMQQQLWTEQYGEAQVIAGDAAQFRLGIPLNKIAEPADIAQAVLFLL
SDNAGHITLHDLRVDGGATLDH