Protein Info for CSW01_03465 in Vibrio cholerae E7946 ATCC 55056

Annotation: GGDEF-domain containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 685 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details transmembrane" amino acids 162 to 182 (21 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 238 to 400 (163 residues), 128 bits, see alignment E=1.4e-41 PF00990: GGDEF" amino acids 242 to 398 (157 residues), 149.9 bits, see alignment E=5.7e-48 PF00563: EAL" amino acids 420 to 655 (236 residues), 250.6 bits, see alignment E=1.4e-78

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A0188)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (685 amino acids)

>CSW01_03465 GGDEF-domain containing protein (Vibrio cholerae E7946 ATCC 55056)
MTKFRKIHSLAFKQAKSVFLVSVLLGLCFSFYHTLSDLHQEQSKVQEHYNFKLVQSYENA
SQAAYHLNNLLAEQVATTLMLDPGIFKVEIVDDFGDVMTRKEKAISEQSQLVSVLASYLT
PAVSVFSAELHQPNSNVVVGKLSFYIDGSSIAKVFIAKTTRVLLFDLLRNTLLTTILLLF
FYQKLSRPITMLITWVNSLNDTQRSPLPLRLTHDDELSELASTFQSMWKGKELAESKLNQ
LAYYDSLTGLANRSLLLQKLSDAIETAQNSHSTGVLFYLDLDRFKTINDSLGHTIGDQLI
KAVALRMEAWTKNDYLSARIGGDEFAVLIPYLSPAKAEEVAKQLLTLISNPYAVDDHQFY
CTVSIGISVFPSVGSCNIDVLRQADTALYRAKASGRNKFMFYEPEMQAQVESFLEIEKGL
HEALNQRQLELFYQPQVDEQHNIIGVEALIRWNHPKRGLLPPGVFMPIAEETGQILPIGN
WIIEQACYQYAQWKKQGILPPHFRRLAINISPLQFAQESFIEQVNHALRQAGITGEPIEL
EITESLLLENVESAIEKMAKLKESQISISIDDFGTGYSSLRYLKHLAVDVLKIDRSFVNQ
LHLDDNDQAIVDTILAIARKLNLEVIAEGVEDTSELAALKKLGCNQFQGYLFDKPLRAEE
IAQRFVSNSYRKIQTLPVATNSLQK