Protein Info for CSW01_03425 in Vibrio cholerae E7946 ATCC 55056

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 50 to 74 (25 residues), see Phobius details amino acids 87 to 110 (24 residues), see Phobius details amino acids 130 to 151 (22 residues), see Phobius details amino acids 160 to 182 (23 residues), see Phobius details amino acids 189 to 210 (22 residues), see Phobius details amino acids 231 to 252 (22 residues), see Phobius details amino acids 263 to 282 (20 residues), see Phobius details amino acids 309 to 331 (23 residues), see Phobius details amino acids 352 to 374 (23 residues), see Phobius details amino acids 383 to 404 (22 residues), see Phobius details amino acids 410 to 430 (21 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 16 to 411 (396 residues), 163.7 bits, see alignment E=3.2e-52 PF01554: MatE" amino acids 16 to 177 (162 residues), 79.8 bits, see alignment E=9.9e-27 amino acids 247 to 399 (153 residues), 42.4 bits, see alignment E=3.2e-15

Best Hits

KEGG orthology group: None (inferred from 100% identity to vcm:VCM66_0608)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (445 amino acids)

>CSW01_03425 MATE family efflux transporter (Vibrio cholerae E7946 ATCC 55056)
MMNRSIYRQFVRYTIPTVAAMLVNGLYQVVDGIFIGHYVGAEGLAGINVAWPVIGTILGI
GMLVGVGTGALASIKQGEGHPDSAKRILATGLMSLLLLAPIVAVILWFMADDFLRWQGAE
GRVFELGLQYLQVLIVGCLFTLGSIAMPFLLRNDHSPNLATLLMVIGALTNIALDYLFIA
WLQWELTGAAIATTLAQVVVTLLGLAYFFSARANMRLTRRCLRLEWHSLPKIFAIGVSSF
FMYAYGSTMVALHNTLMIEYGNAVMVGAYAVMGYIVTIYYLTVEGIANGMQPLASYHFGA
RNYDHIRKLLRLAMGIAVLGGMAFVLVLNLFPEQAIAIFNSSDSELIAGAQMGIKLHLFA
MYLDGFLVVSAAYYQSTNRGGKAMFITVGNMSIMLPFLFILPQFFGLTGVWIALPISNIV
LSTVVGIMLWRDVNKMGKPTQVSYA