Protein Info for CSW01_03275 in Vibrio cholerae E7946 ATCC 55056

Annotation: hybrid sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1129 transmembrane" amino acids 16 to 37 (22 residues), see Phobius details amino acids 356 to 375 (20 residues), see Phobius details PF00672: HAMP" amino acids 375 to 427 (53 residues), 48.2 bits, see alignment 2.7e-16 PF00512: HisKA" amino acids 460 to 526 (67 residues), 56.2 bits, see alignment 7.3e-19 PF02518: HATPase_c" amino acids 574 to 683 (110 residues), 104.1 bits, see alignment E=1.5e-33 PF00072: Response_reg" amino acids 725 to 835 (111 residues), 113.6 bits, see alignment E=1.4e-36 PF13188: PAS_8" amino acids 879 to 918 (40 residues), 20.1 bits, see alignment (E = 1.2e-07)

Best Hits

KEGG orthology group: None (inferred from 100% identity to vcm:VCM66_0580)

Predicted SEED Role

"Chitin catabolic cascade sensor histidine kinase ChiS"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1129 amino acids)

>CSW01_03275 hybrid sensor histidine kinase/response regulator (Vibrio cholerae E7946 ATCC 55056)
MFRFYRKQKFKRLQNTLMAAFLALSIIPLTITALFFLHSHSKDLEQQSTSYLVSVRDNKQ
QQVIDYMMAKESEVMGFVRSELAYASGGRFYGLVNAFQRLDVSIEAAREHAQQRYITGSG
DQIKTSVLPQSSSYVGSERYRLLHKRYHWAYLELLKRSDFDDILLVDIDGNVVYSIYKYD
NFGTNLLTGKYQDTNLGHTFKRLEQTVNEQRKTNEDFTPVVISDFVQEDGKQYAWLGAPI
IQQGYLHSYAMFRLPSNAITKLIAEGSSNPSMQTILVGQDHRSRTLTSAEIAVEKSKAVV
DLALSGKRAVGTYTNTDGEQIIAAYAPINLKNIHWALVVELPEKEAFARVRQLEKLFVFA
MLTAIVLVVIASHYLSNFITSPLLKLTWAAERVSAGDLDEAMINTERKDEIGRLAVSFER
MQRSIREKISLIKSQNKELESNLLIIRKQNDELQLANKLKDEFLATTSHELRTPLHGMIG
IAEALISGANGPISAAHKYQLDIIISSGQRLATLVDDLLDYHKMRYGALDIQRCAVDLSS
ATRLVLELSHHLLGKKTLRIINQVSEQPVWVSADPQRLEQVLYNLIGNAIKYTSEGKIVI
SATYIDDKVRVQVVDTGQGIPAEQLEHIFEPLIQAGHDASRYRQGAGLGLSISRQLIELM
HGTLYVSSQPMVGTTFSFTLPLASEEEIAQARLTELPHFQAPEVLDSELPEQSNLPENEH
GPLLLVADDEPVNLRVLDSFLRLEGYRVHTAQDGHQVLEAIKREKPELVLLDIMMPGMSG
YQVCEKLRQTYDHAELPIIMLTALNQSDDRVRGFEAGANDYLSKPFNKQELAARIVAHLT
ASKAELRRIENAQLQKELKHRAMVEASLLETQGRLLEQLESAPEAILCVKEGNKVRFANE
AAARLFRRTPEQLKRSNAEELIAPKFLNIEQEHYCGNIDVYVDDVRQHLSADVLRLPQGS
GLQAMYIFNVGGSVNAARIHNLETAVEALSSYAFEGDKDKLQKLKELGGEFTRLADKASG
EYQSKQDLMRAVLVEAMTSALNYWERVSGQSKFTFAEQSGLWRVYLDRSTLQTRTLDKYL
RIETLPKTPRWRTVLNSLDYILEHCKEAGPERTHIEMQRDKLQKLLTSE