Protein Info for CSW01_03230 in Vibrio cholerae E7946 ATCC 55056

Annotation: beta-N-acetylhexosaminidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02838: Glyco_hydro_20b
  • amino acids 139 to 255 (117 residues), 84.1 bits, E=1.5e-27
• PF00728: Glyco_hydro_20
  • amino acids 258 to 605 (348 residues), 374.5 bits, E=6.1e-116

Best Hits

Swiss-Prot: 75% identical to HEX1_VIBFU: Beta-hexosaminidase (exoI) from Vibrio furnissii

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 100% identity to vch:VC0613)

MetaCyc: 75% identical to periplasmic beta-N-acetylglucosaminidase (Vibrio furnissii)
Beta-N-acetylhexosaminidase. [EC: 3.2.1.52]; 3.2.1.52 [EC: 3.2.1.52]

Predicted SEED Role

"Beta-N-acetylhexosaminidase, (GlcNAc)2 catabolism"

MetaCyc Pathways

• peptidoglycan recycling I (13/14 steps found)
• peptidoglycan recycling II (6/10 steps found)
• chitin degradation II (Vibrio) (3/6 steps found)
• chitin degradation III (Serratia) (3/7 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glycosaminoglycan degradation
• Glycosphingolipid biosynthesis - ganglio series
• Glycosphingolipid biosynthesis - globo series
• Nucleotide sugars metabolism
• Other glycan degradation

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Protein Sequence (637 amino acids)

>CSW01_03230 beta-N-acetylhexosaminidase (Vibrio cholerae E7946 ATCC 55056)
MSYRIEFAVLSEQKPDCRFGLTLHNLSDQDLHDWSLYFVIDRYIQPMSVTNGQLTQVGSL
CSIVPTEKVLQANGHFYCEFIIKTAPYHFYTDGVKHAFVQLNDKQPVERINVAVNPIVLA
SPFRERSQIPEVTAAELCLIPKPNSLQRFQGEFVVNHSSQISLQSDSAARAARWLEQELH
ALHEFKLNTVGHSDIVYRSNPTLDEGHYQLNIEAQGIKIEAGSHSGFMHASATLLQLAQA
HQGSLRFPLVNIVDAPRFKYRGMMLDCARHFHSLEQVKRVINQLAHYKFNVFHWHLTDDE
GWRIEIKRLPQLTDIGAWRGMDEVLEPQYSLLTERHGGFYTQDEIRAVIEYASDRGITVI
PEIDVPGHSRAAIKALPAWLVDEEDCSQYRSIQYYNDNVLSPALPGTYQFLDIVLEEVAA
LFPSQFIHIGADEVPHGVWVDSPKCQALMQEQGYTDPKELQGHLLRYAEKKLKSLGKRMV
GWEEAHHGDKVSKDTVIYSWLSEKAALDCAKQGFDVILQPGQFTYLDIVQDYAPEEPGVD
WAGVTPLERAYGYEPLADVPANDPLRKRILGIQCALWCELINNSERMEYMLYPRLTALAE
GGWTEKSQRDWLDYLARLKGHLPLLDKQKIPYRAPWK