Protein Info for CSW01_02945 in Vibrio cholerae E7946 ATCC 55056

Annotation: oxaloacetate decarboxylase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 597 PF00682: HMGL-like" amino acids 8 to 269 (262 residues), 78 bits, see alignment E=2.1e-25 TIGR01108: oxaloacetate decarboxylase alpha subunit" amino acids 9 to 592 (584 residues), 885.6 bits, see alignment E=7.6e-271 PF02436: PYC_OADA" amino acids 294 to 495 (202 residues), 203.8 bits, see alignment E=6.1e-64 PF13533: Biotin_lipoyl_2" amino acids 531 to 571 (41 residues), 29.3 bits, see alignment 1.5e-10 PF00364: Biotin_lipoyl" amino acids 531 to 595 (65 residues), 66.1 bits, see alignment E=5.2e-22

Best Hits

Swiss-Prot: 66% identical to DCOA_KLEPN: Oxaloacetate decarboxylase alpha chain (oadA) from Klebsiella pneumoniae

KEGG orthology group: K01571, oxaloacetate decarboxylase, alpha subunit [EC: 4.1.1.3] (inferred from 100% identity to vco:VC0395_A0085)

Predicted SEED Role

"Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3)" in subsystem Na+ translocating decarboxylases and related biotin-dependent enzymes or Pyruvate metabolism I: anaplerotic reactions, PEP (EC 4.1.1.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.3

Use Curated BLAST to search for 4.1.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (597 amino acids)

>CSW01_02945 oxaloacetate decarboxylase subunit alpha (Vibrio cholerae E7946 ATCC 55056)
MSMSKPLAITDVVLRDAHQSLFATRMRIEDMLPIAAELDKIGYWSLETWGGATFDACIRF
LGEDPWERLRALKKAMPNTPMQMLLRGQNLLGYRHYADDVVEKFVERAHVNGMDVFRIFD
AMNDVRNFEKAVKATIGVGAHAQGTLSYTTSPVHNTQTWVDLAKRLEDLGCHSLCIKDMS
GLLKPYEAEELITRIKQSCAVPLALHCHATTGLSTATAVKAVEAGIDILDTAISSMSQTY
GHTPTETVVAMLQDTPRDTQLKLEQLEPIAAYFREVRKKYAKFEGQLKGVDSRILIAQVP
GGMLTNMESQLKEQGAAHRIDEVLEEIPRVRQDLGFIPLVTPTSQIVGTQAVINVLTGER
YKSITKETAGVLKGEYGATPASVNAELQARVLEGGQAITCRPADLLQDELDHLTKELLEK
AQVEKITLADAKVDDVLTYALFPQVGLKFLKNRHNPEAFEPAPGKEPAPVATAPASTKPA
AGIESYSVKVDGVVYDVEVGSQGQLTSVVPAGQKAAPKLAVATPTQGAEAVAAPLAGTIF
KIQVEQGDEVAEGDVLIVLEAMKMETEIRAARSGVIQELHVKEGDSVRVGASLLSLA