Protein Info for CSW01_02465 in Vibrio cholerae E7946 ATCC 55056

Annotation: twitching motility protein PilT

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 368 TIGR01420: twitching motility protein" amino acids 3 to 342 (340 residues), 423.3 bits, see alignment E=3.8e-131 PF00437: T2SSE" amino acids 3 to 273 (271 residues), 151.5 bits, see alignment E=1.3e-48

Best Hits

Swiss-Prot: 39% identical to YGGR_ECOLI: Uncharacterized protein YggR (yggR) from Escherichia coli (strain K12)

KEGG orthology group: K02670, twitching motility protein PilU (inferred from 100% identity to vco:VC0395_A0015)

Predicted SEED Role

"Twitching motility protein PilT" in subsystem Type IV pilus

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (368 amino acids)

>CSW01_02465 twitching motility protein PilT (Vibrio cholerae E7946 ATCC 55056)
MELNQYLDGMLTHKASDLYITVGAPILYRVDGELRAQGEALSVADVTALLHAMMDDARQA
EFKQTREANFAVVRDSGRFRVSAFFQRELPGAVIRRIETRIPTFEELKLPEVLQNLAIAK
RGLVLVVGATGSGKSTTMAAMTGYRNQHRTGHILTVEDPIEFVHEHKRCIVTQREVGLDT
ESYEVALKNSLRQAPDMILIGEIRSRETMEYAMTFAETGHLCMATLHANNANQALERILH
LVPKEQREQFLLDLSLNLKGVIAQQLLRDKNGKGRHGVFEVLLNSPRIADLIRRGELHEL
KATMARSQEVGMQTFDQALYQLVVDDKISEQDALHSADSANDLRLMLKTKRGDDYGSGSL
QNVKIDME