Protein Info for CSW01_02275 in Vibrio cholerae E7946 ATCC 55056

Annotation: arginine:ornithine antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 37 to 61 (25 residues), see Phobius details amino acids 88 to 113 (26 residues), see Phobius details amino acids 127 to 146 (20 residues), see Phobius details amino acids 164 to 183 (20 residues), see Phobius details amino acids 204 to 223 (20 residues), see Phobius details amino acids 235 to 259 (25 residues), see Phobius details amino acids 285 to 312 (28 residues), see Phobius details amino acids 333 to 354 (22 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 392 to 408 (17 residues), see Phobius details amino acids 414 to 431 (18 residues), see Phobius details amino acids 445 to 465 (21 residues), see Phobius details TIGR00905: transporter, basic amino acid/polyamine antiporter (APA) family" amino acids 3 to 466 (464 residues), 533.6 bits, see alignment E=2.2e-164 PF13520: AA_permease_2" amino acids 5 to 409 (405 residues), 227.9 bits, see alignment E=2.4e-71 PF00324: AA_permease" amino acids 13 to 427 (415 residues), 94.2 bits, see alignment E=7.7e-31

Best Hits

Swiss-Prot: 60% identical to ARCD_ECOL6: Putative arginine/ornithine antiporter (ydgI) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03758, arginine:ornithine antiporter (inferred from 100% identity to vco:VC0395_A2851)

Predicted SEED Role

"Arginine/ornithine antiporter ArcD" in subsystem Arginine Deiminase Pathway or Arginine and Ornithine Degradation or Polyamine Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (468 amino acids)

>CSW01_02275 arginine:ornithine antiporter (Vibrio cholerae E7946 ATCC 55056)
MDKKLGLGSLTALVIGSMIGAGVFSLPQNMAAVASPLAVMIGWSITGIGMIFLALSFQYL
AVNKPHVNSGVFGFAREGFGDFAGFCSAWGYWFSAMVANVSYLVIVFSTLGLLFDTPDQI
IFGSGNTWWSIGGASLLLWAVHSLVLRGVQTAALINLITTMTKMVPLLLFIVSAIAAFNW
STFSLDFAGLHHISGADLLGQVKATMLITVWVFVGIEGAVVVSSRARQRKDIGRATILGL
LTALSIYVLVTLLSMGVIQVNQLAQYPNPSMAQVLTTIIGPWGKYIIAVGLLISVCGAFL
SWTVLASEAPFLAAKDKMFPRHFAKQNQAGSPVNALFLTTLCIQVSLILVRYTSSTYDSL
LIFASEMILVPYFLVGAFTLKLALEQRDRGKLLLIGFGATAYGLWLLYASGLHYLMLSTL
LYVPGFAFYLKAKREQGVKAFCGREMVGASTLLLFAVGAAGMLWQGAW