Protein Info for CSW01_02120 in Vibrio cholerae E7946 ATCC 55056

Annotation: pilus (MSHA type) biogenesis protein MshL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 559 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF07655: Secretin_N_2" amino acids 145 to 248 (104 residues), 74.1 bits, see alignment E=1.1e-24 TIGR02519: pilus (MSHA type) biogenesis protein MshL" amino acids 242 to 535 (294 residues), 362.7 bits, see alignment E=5.7e-113 PF00263: Secretin" amino acids 360 to 535 (176 residues), 136.8 bits, see alignment E=5.9e-44

Best Hits

KEGG orthology group: K12282, MSHA biogenesis protein MshL (inferred from 100% identity to vch:VC0402)

Predicted SEED Role

"MSHA biogenesis protein MshL" in subsystem Mannose-sensitive hemagglutinin type 4 pilus

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (559 amino acids)

>CSW01_02120 pilus (MSHA type) biogenesis protein MshL (Vibrio cholerae E7946 ATCC 55056)
MRKIVLASVVTSLVGCSMGHRDPVEAKQALNQAINETNSRQIDQLPPSVEADLMPDMDTL
TASEPKTLQRFRIQAEDVEAKAFFASLVQGTEYSAAIHPAVTGRITLNLTDVTLDEALGV
VRDLYGFEVVKEGKVIQVYPAGLRTVTIPVDYLQFKRTGRSLTSITTGTITNTDTNNSNS
SSSSSSSISSNSSSDGSSSNSNSNRSDARGGTEIETTNESDFWPLLEKAVAQLLGGSGGQ
TVIVNPQAGVLTLRAYPDEIRQVNEFLGISQQRMHRQVILEAKILEVTLSDGYQQGINWS
KAFSSNGANYKIGSGSITQDSNGNPITSVLPGLDAIGNLLGGQSNVVISSGSFDAVISFM
ATQGDLNVLSSPRVTASNNQKAVIKVGTDEYYVTDLSSVVGTGDNAQASPDITLTPFFSG
ISLDVTPQIDDQGNVLLHVHPAVIEVEQQTKKILYRSEEIELPLARSSIRESDSVIRAKD
GDVVVIGGLMKSNTVDQVSKVPFLGDVPALGHLFRNTTKLTQKTELVILLKPTVVGVNTW
QKELERSRSLLQEWFPDSQ